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rgs6.L regulator of G-protein signaling 6 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 379636, updated on 4-Nov-2024

Summary

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Official Symbol
rgs6.L
Official Full Name
regulator of G-protein signaling 6 L homeolog
Primary source
Xenbase:XB-GENE-17341706
Locus tag
XELAEV_18039893mg
See related
EnsemblRapid:ENSXLAG00005026499 AllianceGenome:Xenbase:XB-GENE-17341706
Gene type
protein coding
RefSeq status
PREDICTED
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Summary
Predicted to enable GTPase activator activity. Predicted to act upstream of or within several processes, including G protein-coupled receptor signaling pathway; positive regulation of GTPase activity; and regulation of signal transduction. Predicted to be located in cytoplasm and neuron projection. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human RGS6 (regulator of G protein signaling 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rgs6.L in Genome Data Viewer
Location:
chromosome: 8L
Exon count:
19
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8L NC_054385.1 (98382719..98610473, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8L NC_030738.1 (83709205..83937733, complement)

Chromosome 8L - NC_054385.1Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 4 L homeolog Neighboring gene D4, zinc and double PHD fingers, family 3 L homeolog Neighboring gene uncharacterized LOC121397140 Neighboring gene signal induced proliferation associated 1 like 1 L homeolog Neighboring gene pecanex 1 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC68862

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC379636

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086476.1 → NP_001079945.1  uncharacterized protein LOC379636

    See identical proteins and their annotated locations for NP_001079945.1

    Status: PREDICTED

    Source sequence(s)
    BC057714
    UniProtKB/TrEMBL
    A0A974C8M3, A0A974H555, Q6PF63
    Related
    ENSXLAP00005079014.1, ENSXLAT00005080605.1
    Conserved Domains (3) summary
    smart00224
    Location:257 → 318
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:327 → 451
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:30 → 118
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054385.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    98382719..98610473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041571900.1 → XP_041427834.1  uncharacterized protein LOC379636 isoform X2

    UniProtKB/TrEMBL
    A0A1L8FAI1, A0A974C950, A0A974H555
    Related
    ENSXLAP00005078881.1, ENSXLAT00005080472.1
    Conserved Domains (4) summary
    smart00224
    Location:257 → 318
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:327 → 451
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:30 → 118
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    pfam18148
    Location:115 → 216
    RGS_DHEX; Regulator of G-protein signalling DHEX domain

  2. XM_041571899.1 → XP_041427833.1  uncharacterized protein LOC379636 isoform X1

    UniProtKB/TrEMBL
    A0A8J1LE68
    Conserved Domains (4) summary
    smart00224
    Location:267 → 328
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:337 → 461
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:40 → 128
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    pfam18148
    Location:125 → 226
    RGS_DHEX; Regulator of G-protein signalling DHEX domain

  3. XM_041571901.1 → XP_041427835.1  uncharacterized protein LOC379636 isoform X3

    UniProtKB/TrEMBL
    A0A8J1LGM3, A0A974H555
    Related
    ENSXLAP00005079254.1, ENSXLAT00005080845.1
    Conserved Domains (4) summary
    smart00224
    Location:267 → 328
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:337 → 461
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:40 → 128
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    pfam18148
    Location:125 → 226
    RGS_DHEX; Regulator of G-protein signalling DHEX domain
Nucleotide Protein Strain
Heading Accession and Version

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