kif2a.L kinesin heavy chain member 2A L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: kif2a.L
Official Full Name: kinesin heavy chain member 2A L homeolog
Primary source: Xenbase:XB-GENE-951759
Locus tag: XELAEV_18008243mg
See related: EnsemblRapid:ENSXLAG00005027156 AllianceGenome:Xenbase:XB-GENE-951759
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: KIF2; kif2a; kif2-a
Summary: Predicted to enable ATP binding activity; microtubule binding activity; and microtubule motor activity. Predicted to act upstream of or within mitotic spindle organization. Predicted to be located in cytoplasm and microtubule cytoskeleton. Predicted to colocalize with spindle microtubule and spindle pole. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 3. Orthologous to human KIF2A (kinesin family member 2A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 1L

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1L	NC_054371.1 (205893384..205941067, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1L	NC_030724.1 (192714665..192762532, complement)

Chromosome 1L - NC_054371.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interaction between kif2a and importin-alpha could be the mechanism by which spindle and cell sizes are coordinated early in development.
Title: Mitotic spindle scaling during Xenopus development by kif2a and importin α.
Kif2a is required for the epiboly (spreading) of animal cap. In animal caps, Kif2a localizes to the spindle poles (centrosomes) and centromeres during mitosis and is required for spindle integrity and proper chromosome segregation.
Title: Kif2a depletion generates chromosome segregation and pole coalescence defects in animal caps and inhibits gastrulation of the Xenopus embryo.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within microtubule-based movement	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic spindle organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in spindle	IEA Inferred from Electronic Annotation more info
colocalizes_with spindle microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info
colocalizes_with spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: kinesin-like protein KIF2A

Names: kinesin-related protein XKIF2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086462.1 → NP_001079931.1 kinesin-like protein KIF2A

See identical proteins and their annotated locations for NP_001079931.1

Status: PROVISIONAL

Source sequence(s)

U36486

UniProtKB/Swiss-Prot

Q91637

Conserved Domains (2) summary

cd01367
Location:222 → 550

KISc_KIF2_like; Kinesin motor domain, KIF2-like group

pfam00225
Location:228 → 551

Kinesin; Kinesin motor domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

205893384..205941067 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041591332.1 → XP_041447266.1 kinesin-like protein KIF2A isoform X4

UniProtKB/Swiss-Prot

Q91637

UniProtKB/TrEMBL

A0A8J1N0L9

Conserved Domains (1) summary

cd01367
Location:205 → 533

KISc_KIF2_like; Kinesin motor domain, KIF2-like group
XM_041591306.1 → XP_041447240.1 kinesin-like protein KIF2A isoform X3

UniProtKB/Swiss-Prot

Q91637

UniProtKB/TrEMBL

A0A8J1N224

Conserved Domains (1) summary

cd01367
Location:207 → 535

KISc_KIF2_like; Kinesin motor domain, KIF2-like group
XM_018264389.2 → XP_018119878.1 kinesin-like protein KIF2A isoform X2

UniProtKB/Swiss-Prot

Q91637

UniProtKB/TrEMBL

A0A8J0VD83

Related

ENSXLAP00005080895.1, ENSXLAT00005082502.1
XM_041591246.1 → XP_041447180.1 kinesin-like protein KIF2A isoform X1

UniProtKB/Swiss-Prot

Q91637

UniProtKB/TrEMBL

A0A8J1N1V4

Related

ENSXLAP00005081316.1, ENSXLAT00005082927.1

Conserved Domains (1) summary

cd01367
Location:226 → 554

KISc_KIF2_like; Kinesin motor domain, KIF2-like group
XM_018264242.2 → XP_018119731.1 kinesin-like protein KIF2A isoform X6

UniProtKB/Swiss-Prot

Q91637

UniProtKB/TrEMBL

A0A1L8I266, A0A974E2M8

Related

ENSXLAP00005081469.1, ENSXLAT00005083079.1
XM_018264211.2 → XP_018119700.1 kinesin-like protein KIF2A isoform X5

UniProtKB/Swiss-Prot

Q91637

UniProtKB/TrEMBL

A0A8J0VIH8

Related

ENSXLAP00005081763.1, ENSXLAT00005083374.1
XM_018264330.2 → XP_018119819.1 kinesin-like protein KIF2A isoform X7

UniProtKB/Swiss-Prot

Q91637

UniProtKB/TrEMBL

A0A974E2B9, Q6PF78

Related

ENSXLAP00005081624.1, ENSXLAT00005083235.1