trim72.L tripartite motif containing 72, E3 ubiquitin protein ligase L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: trim72.L
Official Full Name: tripartite motif containing 72, E3 ubiquitin protein ligase L homeolog
Primary source: Xenbase:XB-GENE-5896500
Locus tag: XELAEV_18001508mg
See related: EnsemblRapid:ENSXLAG00005018435 AllianceGenome:Xenbase:XB-GENE-5896500
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: Mg53; trim72
Summary: Predicted to enable phosphatidylserine binding activity. Predicted to act upstream of or within several processes, including muscle organ development; plasma membrane repair; and protein homooligomerization. Predicted to be located in cytoplasmic vesicle membrane and sarcolemma. Orthologous to human TRIM72 (tripartite motif containing 72). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 9_10L

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10L	NC_054387.1 (133107850..133114873)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	Unplaced Scaffold	NW_016694813.1 (3036654..3043677, complement)

Chromosome 9_10L - NC_054387.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylserine binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within exocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle organ development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within muscle system process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within plasma membrane repair	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein homooligomerization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: tripartite motif-containing protein 72

Names: Mitsugumin-53; tripartite motif-containing 72

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086453.2 → NP_001079922.1 tripartite motif-containing protein 72

See identical proteins and their annotated locations for NP_001079922.1

Status: PROVISIONAL

Source sequence(s)

BC056854

UniProtKB/Swiss-Prot

Q6PGR9

Related

ENSXLAP00005054475.1, ENSXLAT00005055649.1

Conserved Domains (3) summary

pfam00643
Location:83 → 123

zf-B_box; B-box zinc finger

cd13742
Location:280 → 470

SPRY_PRY_TRIM72; PRY/SPRY domain in tripartite motif-binding protein 72 (TRIM72)

cl17238
Location:16 → 58

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...