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sqstm1.L sequestosome 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 379610, updated on 18-Sep-2024

Summary

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Official Symbol
sqstm1.L
Official Full Name
sequestosome 1 L homeolog
Primary source
Xenbase:XB-GENE-5919104
Locus tag
XELAEV_18016927mg
See related
EnsemblRapid:ENSXLAG00005001591
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
p62; sqstm1
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Genomic context

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See sqstm1.L in Genome Data Viewer
Location:
chromosome: 3L
Exon count:
8
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3L NC_054375.1 (27281885..27290668, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3L NC_030728.1 (14366307..14375090, complement)

Chromosome 3L - NC_054375.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 2, gene 2 L homeolog Neighboring gene zona pellucida glycoprotein 4 L homeolog Neighboring gene uncharacterized LOC108710827 Neighboring gene TBC1 domain family member 9B L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer. Puvirajesinghe TM, et al. Nat Commun, 2016 Jan 12. PMID 26754771, Free PMC Article
  2. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Kırlı K, et al. Elife, 2015 Dec 17. PMID 26673895, Free PMC Article
  3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC64432

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase C binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_positive_effect JNK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within aggrephagy IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within endosome organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitophagy IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neural tube closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within non-canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in aggresome IEA
Inferred from Electronic Annotation
more info
  
located_in amphisome IEA
Inferred from Electronic Annotation
more info
  
located_in autophagosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sequestosome 1 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086451.2 → NP_001079920.1  sequestosome 1 L homeolog

    See identical proteins and their annotated locations for NP_001079920.1

    Status: PROVISIONAL

    Source sequence(s)
    BC056852
    UniProtKB/TrEMBL
    A0A974HSC5, Q6PGS1
    Related
    ENSXLAP00005004751.1, ENSXLAT00005004848.1
    Conserved Domains (3) summary
    cd06402
    Location:3 → 99
    PB1_p62; The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which ...
    cd02340
    Location:123 → 165
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cl21463
    Location:393 → 452
    UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    27281885..27290668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Research Materials