ywhaz.L tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: ywhaz.L
Official Full Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta L homeolog
Primary source: Xenbase:XB-GENE-6256657
Locus tag: XELAEV_18032253mg
See related: EnsemblRapid:ENSXLAG00005033706 AllianceGenome:Xenbase:XB-GENE-6256657
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: ywhaz; ywhazb; 14-3-3z; ywhaz-a; ywhaz-b; ywhaz.S; 14-3-3zeta
Summary: Predicted to enable phosphoserine residue binding activity and protein sequestering activity. Predicted to act upstream of or within regulation of ERK1 and ERK2 cascade. Predicted to be located in cytoplasm. Is expressed in musculoskeletal system; nervous system; and visual system. Orthologous to human YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 6L

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	6L	NC_054381.1 (141333097..141363366, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	6L	NC_030734.1 (132170945..132201389, complement)

Chromosome 6L - NC_054381.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Collectively, these results demonstrate that14-3-3/14-3-3varsigma participates in the regulation of retinal axon elongation, in part by modulating XAC activity.
Title: 14-3-3 proteins regulate retinal axon growth by modulating ADF/cofilin activity.
Caspase-2 phosphorylated at S135 binds 14-3-3zeta, thus preventing C2 dephosphorylation.
Title: Metabolic control of oocyte apoptosis mediated by 14-3-3zeta-regulated dephosphorylation of caspase-2.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables phosphoserine residue binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein sequestering activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 14-3-3 protein zeta

Names: 14-3-3 zeta; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta S homeolog; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086449.1 → NP_001079918.1 14-3-3 protein zeta

See identical proteins and their annotated locations for NP_001079918.1

Status: PROVISIONAL

Source sequence(s)

BC056850

UniProtKB/Swiss-Prot

O57469, Q91896

UniProtKB/TrEMBL

A0A974HGJ9, Q6PGS3

Related

ENSXLAP00005100608.1, ENSXLAT00005102567.1

Conserved Domains (1) summary

cl02098
Location:2 → 230

14-3-3; 14-3-3 domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054381.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

141333097..141363366 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)