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KIF2A kinesin family member 2A [ Homo sapiens (human) ]

Gene ID: 3796, updated on 7-Apr-2024

Summary

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Official Symbol
KIF2Aprovided by HGNC
Official Full Name
kinesin family member 2Aprovided by HGNC
Primary source
HGNC:HGNC:6318
See related
Ensembl:ENSG00000068796 MIM:602591; AllianceGenome:HGNC:6318
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HK2; KIF2; CDCBM3
Summary
The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Expression
Broad expression in testis (RPKM 17.8), brain (RPKM 16.2) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
5q12.1
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (62306206..62391025)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (63125434..63210585)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (61602033..61686852)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900610 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:61306801-61307329 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:61339008-61339553 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:61339554-61340098 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:61370472-61371439 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:61457226-61457726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:61457727-61458227 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:61458278-61458778 Neighboring gene RN7SK pseudogene 157 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:61532143-61532644 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:61532645-61533144 Neighboring gene CRISPRi-validated cis-regulatory element chr5.1488 Neighboring gene Sharpr-MPRA regulatory region 4645 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22595 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16051 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:61610189-61610690 Neighboring gene CREB regulated transcription coactivator 2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22596 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22597 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16052 Neighboring gene DIM1 rRNA methyltransferase and ribosome maturation factor Neighboring gene RNA, U6 small nuclear 661, pseudogene Neighboring gene importin 11 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:61791875-61792070 Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Kinesin family member 2A links with advanced tumor stage, reduced chemosensitivity and worse prognosis in gastric cancer. Bai F, et al. J Clin Lab Anal, 2022 May. PMID 35313389, Free PMC Article
  2. Clinical significance of kinesin family member 2A as a facilitating biomarker of disease surveillance and prognostication in cervical cancer patients. Lei G, et al. Ir J Med Sci, 2022 Apr. PMID 33797694
  3. Variants in KIF2A cause broad clinical presentation; the computational structural analysis of a novel variant in a patient with a cortical dysplasia, complex, with other brain malformations 3. Hatano M, et al. Am J Med Genet A, 2021 Apr. PMID 33506645
  4. Association of kinesin family member 2A with increased disease risk, deteriorative clinical characteristics, and shorter survival profiles in acute myeloid leukemia. Ding T, et al. Braz J Med Biol Res, 2020. PMID 33331418, Free PMC Article
  5. Identification of Kinesin Family Member 2A (KIF2A) as a Promising Therapeutic Target for Osteosarcoma. Wang ZX, et al. Biomed Res Int, 2020. PMID 33204709, Free PMC Article

See all (144) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NuSAP regulates microtubule flux and Kif2A localization to ensure accurate chromosome congression.
    Title: NuSAP regulates microtubule flux and Kif2A localization to ensure accurate chromosome congression.
  2. The minus-end depolymerase KIF2A drives flux-like treadmilling of gammaTuRC-uncapped microtubules.
    Title: The minus-end depolymerase KIF2A drives flux-like treadmilling of ÎłTuRC-uncapped microtubules.
  3. Kinesin family member 2A links with advanced tumor stage, reduced chemosensitivity and worse prognosis in gastric cancer.
    Title: Kinesin family member 2A links with advanced tumor stage, reduced chemosensitivity and worse prognosis in gastric cancer.
  4. Clinical significance of kinesin family member 2A as a facilitating biomarker of disease surveillance and prognostication in cervical cancer patients.
    Title: Clinical significance of kinesin family member 2A as a facilitating biomarker of disease surveillance and prognostication in cervical cancer patients.
  5. Variants in KIF2A cause broad clinical presentation; the computational structural analysis of a novel variant in a patient with a cortical dysplasia, complex, with other brain malformations 3.
    Title: Variants in KIF2A cause broad clinical presentation; the computational structural analysis of a novel variant in a patient with a cortical dysplasia, complex, with other brain malformations 3.
  6. Separable roles for RanGTP in nuclear and ciliary trafficking of a kinesin-2 subunit.
    Title: Separable roles for RanGTP in nuclear and ciliary trafficking of a kinesin-2 subunit.
  7. Long Non-Coding RNA Paternally Expressed Imprinted Gene 10 (PEG10) Elevates Diffuse Large B-Cell Lymphoma Progression by Regulating Kinesin Family Member 2A (KIF2A) via Targeting MiR-101-3p.
    Title: Long Non-Coding RNA Paternally Expressed Imprinted Gene 10 (PEG10) Elevates Diffuse Large B-Cell Lymphoma Progression by Regulating Kinesin Family Member 2A (KIF2A) via Targeting MiR-101-3p.
  8. Identification of Kinesin Family Member 2A (KIF2A) as a Promising Therapeutic Target for Osteosarcoma.
    Title: Identification of Kinesin Family Member 2A (KIF2A) as a Promising Therapeutic Target for Osteosarcoma.
  9. Reciprocal regulation of Aurora kinase A and ATIP3 in the control of metaphase spindle length.
    Title: Reciprocal regulation of Aurora kinase A and ATIP3 in the control of metaphase spindle length.
  10. Association of kinesin family member 2A with increased disease risk, deteriorative clinical characteristics, and shorter survival profiles in acute myeloid leukemia.
    Title: Association of kinesin family member 2A with increased disease risk, deteriorative clinical characteristics, and shorter survival profiles in acute myeloid leukemia.
Submit: New GeneRIF Correction See all GeneRIFs (45)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Complex cortical dysplasia with other brain malformations 3
MedGen: C3809414 OMIM: 615411 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat downregulates the abundance of kinesin heavy chain member 2A (KIF2A) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytoskeletal motor activity TAS
Traceable Author Statement
more info
 PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in microtubule depolymerization TAS
Traceable Author Statement
more info
 PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of centriolar subdistal appendage IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane HDA PubMed 
colocalizes_with microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with spindle microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kinesin-like protein KIF2A
Names
Kinesin, heavy chain, 2
kinesin heavy chain member 2A
kinesin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042185.2 RefSeqGene

    Range
    5002..89821
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001098511.3 → NP_001091981.1  kinesin-like protein KIF2A isoform 2

    See identical proteins and their annotated locations for NP_001091981.1

    Status: REVIEWED

    Source sequence(s)
    AC016637, AC034242
    Consensus CDS
    CCDS47216.1
    UniProtKB/TrEMBL
    B4DM85
    Related
    ENSP00000385000.3, ENST00000407818.8
    Conserved Domains (2) summary
    smart00129
    Location:223 → 559
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01367
    Location:223 → 551
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

  2. NM_001243952.2 → NP_001230881.2  kinesin-like protein KIF2A isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC016637, AC034242, BC047544
    Consensus CDS
    CCDS58949.2
    UniProtKB/TrEMBL
    A0A6Q8PGH7
    Related
    ENSP00000370493.3, ENST00000381103.7
    Conserved Domains (1) summary
    cd01367
    Location:196 → 524
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

  3. NM_001243953.2 → NP_001230882.1  kinesin-like protein KIF2A isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC016637, AI652174, AK315866, DB452624, DB456309
    Consensus CDS
    CCDS93716.1
    UniProtKB/TrEMBL
    A0A6Q8PFA6, B0AZS5
    Related
    ENSP00000501719.1, ENST00000676271.1
    Conserved Domains (2) summary
    smart00129
    Location:204 → 539
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01367
    Location:204 → 532
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

  4. NM_004520.5 → NP_004511.2  kinesin-like protein KIF2A isoform 1

    See identical proteins and their annotated locations for NP_004511.2

    Status: REVIEWED

    Source sequence(s)
    AC016637, AI652174, DB456309, EF560728
    Consensus CDS
    CCDS3980.2
    UniProtKB/Swiss-Prot
    A5YM42, A5YM54, B4DY54, D3DW97, E9PB70, O00139, Q7Z5I3, Q8N5Q7
    UniProtKB/TrEMBL
    A0A6Q8PGH7
    Related
    ENSP00000385622.3, ENST00000401507.7
    Conserved Domains (2) summary
    smart00129
    Location:223 → 558
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01367
    Location:223 → 551
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    62306206..62391025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    63125434..63210585
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O00139.3 GenPept UniProtKB/Swiss-Prot:O00139

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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