sesn1.L sestrin 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: sesn1.L
Official Full Name: sestrin 1 L homeolog
Primary source: Xenbase:XB-GENE-866080
Locus tag: XELAEV_18027202mg
See related: EnsemblRapid:ENSXLAG00005034486 AllianceGenome:Xenbase:XB-GENE-866080
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: PA26; sesn1; sesn1-A
Summary: Predicted to enable L-leucine binding activity. Predicted to act upstream of or within negative regulation of TORC1 signaling. Predicted to be located in cytoplasm and nucleus. Predicted to be part of GATOR2 complex. Is expressed in ectoderm. Orthologous to human SESN1 (sestrin 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 5L

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5L	NC_054379.1 (81458295..81595071)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5L	NC_030732.1 (79376843..79389637)

Chromosome 5L - NC_054379.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables L-leucine binding	IEA Inferred from Electronic Annotation more info
enables L-leucine binding	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on peroxide as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to L-leucine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to leucine starvation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of TORC1 signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of macroautophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of response to reactive oxygen species	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of GATOR2 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: sestrin-1

Names: XPA26; nuclear factor XPA26-T2; p53-regulated protein PA26; sestrin 1,nuclear factor XPA26-T2

NP_001079869.1

EC 1.11.1.15

XP_041418007.1

EC 1.11.1.15

XP_041418008.1

EC 1.11.1.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.