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prdm12.L PR domain containing 12 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 379544, updated on 4-Nov-2024

Summary

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Official Symbol
prdm12.L
Official Full Name
PR domain containing 12 L homeolog
Primary source
Xenbase:XB-GENE-953734
Locus tag
XELAEV_18003346mg
See related
EnsemblRapid:ENSXLAG00005022020 AllianceGenome:Xenbase:XB-GENE-953734
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
pfm9; prdm12
Summary
Enables histone chaperone activity. Acts upstream of or within protein methylation. Predicted to be located in nucleus. Is expressed in ectoderm and nervous system. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 8. Orthologous to human PRDM12 (PR/SET domain 12). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
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Genomic context

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See prdm12.L in Genome Data Viewer
Location:
chromosome: 8L
Exon count:
5
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8L NC_054385.1 (8877245..8885268, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) Unplaced Scaffold NW_016694837.1 (929194..1003012)

Chromosome 8L - NC_054385.1Genomic Context describing neighboring genes Neighboring gene ABL proto-oncogene 1, non-receptor tyrosine kinase L homeolog Neighboring gene exosome component 2 L homeolog Neighboring gene far upstream element binding protein 3 L homeolog Neighboring gene argininosuccinate synthase 1 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The requirement of histone modification by PRDM12 and Kdm4a for the development of pre-placodal ectoderm and neural crest in Xenopus. Matsukawa S, et al. Dev Biol, 2015 Mar 1. PMID 25576027
  2. Transcriptional regulator PRDM12 is essential for human pain perception. Chen YC, et al. Nat Genet, 2015 Jul. PMID 26005867, Free PMC Article
  3. Prdm12 specifies V1 interneurons through cross-repressive interactions with Dbx1 and Nkx6 genes in Xenopus. Thélie A, et al. Development, 2015 Oct 1. PMID 26443638, Free PMC Article
  4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Prdm12 specifies V1 interneurons through cross-repressive interactions with Dbx1 and Nkx6 genes in Xenopus.
    Title: Prdm12 specifies V1 interneurons through cross-repressive interactions with Dbx1 and Nkx6 genes in Xenopus.
  2. Data indicate the requirement of histone modification by PR domain containing 12 (PRDM12) and histone demethylase Kdm4a for pre-placodal ectoderm and neural crest development.
    Title: The requirement of histone modification by PRDM12 and Kdm4a for the development of pre-placodal ectoderm and neural crest in Xenopus.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC68944

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables histone chaperone activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone methyltransferase binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neurogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein methylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
PR domain containing 12 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086385.1 → NP_001079854.1  PR domain containing 12 L homeolog

    See identical proteins and their annotated locations for NP_001079854.1

    Status: PROVISIONAL

    Source sequence(s)
    BC056019
    UniProtKB/TrEMBL
    Q7T0V8
    Related
    ENSXLAP00005064664.1, ENSXLAT00005066178.1
    Conserved Domains (5) summary
    COG5048
    Location:245 → 295
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:246 → 266
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:245 → 266
    zf-C2H2; Zinc finger, C2H2 type
    pfam00856
    Location:99 → 203
    SET; SET domain
    pfam13465
    Location:258 → 283
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054385.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    8877245..8885268 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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