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hsd11b1.L hydroxysteroid (11-beta) dehydrogenase 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 379497, updated on 4-Nov-2024

Summary

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Official Symbol
hsd11b1.L
Official Full Name
hydroxysteroid (11-beta) dehydrogenase 1 L homeolog
Primary source
Xenbase:XB-GENE-960494
Locus tag
XELAEV_18011953mg
See related
EnsemblRapid:ENSXLAG00005030435 AllianceGenome:Xenbase:XB-GENE-960494
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
hsd11; hsd11b; hsd11b1
Summary
Predicted to enable 11-beta-hydroxysteroid dehydrogenase (NADP+) activity and steroid binding activity. Predicted to act upstream of or within steroid catabolic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in cortisone reductase deficiency (multiple); hypertension (multiple); and type 2 diabetes mellitus. Orthologous to human HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hsd11b1.L in Genome Data Viewer
Location:
chromosome: 2L
Exon count:
6
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2L NC_054373.1 (52284039..52291132, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2L NC_030726.1 (50206201..50213294, complement)

Chromosome 2L - NC_054373.1Genomic Context describing neighboring genes Neighboring gene chromosome 2 C1orf74 homolog L homeolog Neighboring gene TRAF3 interacting protein 3 L homeolog Neighboring gene uncharacterized LOC108708049 Neighboring gene laminin subunit beta-3-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC64545

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables steroid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within steroid catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
hydroxysteroid (11-beta) dehydrogenase 1 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086338.1 → NP_001079807.1  hydroxysteroid (11-beta) dehydrogenase 1 L homeolog

    See identical proteins and their annotated locations for NP_001079807.1

    Status: PROVISIONAL

    Source sequence(s)
    BC054291
    UniProtKB/TrEMBL
    A0A974DMV5, Q7SYR9
    Related
    ENSXLAP00005090934.1, ENSXLAT00005092614.1
    Conserved Domains (2) summary
    cd05332
    Location:31 → 279
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
    pfam00106
    Location:34 → 229
    adh_short; short chain dehydrogenase

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054373.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    52284039..52291132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials