Mmp1 Matrix metalloproteinase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mmp1provided by FlyBase
Official Full Name: Matrix metalloproteinase 1provided by FlyBase
Primary source: FLYBASE:FBgn0035049
Locus tag: Dmel_CG4859
See related: AllianceGenome:FB:FBgn0035049
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4859; dm1-MMP; Dm1-MMP; Dmel\CG4859; dmmp1; dMMP1; l(2)k04809; MMP; Mmp 1; mmp-1; Mmp-1; MMP-1; mmp1; MMp1; MMP1
Summary: Enables metalloendopeptidase activity. Involved in several processes, including instar larval or pupal development; nervous system development; and open tracheal system development. Located in dendrite; extracellular space; and plasma membrane. Is expressed in several structures, including adult head; dorsal median cell; epithelium; gut section; and imaginal disc. Orthologous to human MMP16 (matrix metallopeptidase 16) and MMP24 (matrix metallopeptidase 24). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 60D13-60D14; 2-107 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (24671294..24688184, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (20558817..20575707, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fear-of-intimacy-mediated zinc transport controls fat body cell dissociation through modulating Mmp activity in Drosophila.
Title: Fear-of-intimacy-mediated zinc transport controls fat body cell dissociation through modulating Mmp activity in Drosophila.
Matrix metalloproteinase 1 (MMP1) is required in tracheal cells for normal invasion speed and for the dynamic organization of growth-cone-like branch tips. MMP1 remodels the CollagenIV-containing matrix around branch tips, which show differential matrix composition with low CollagenIV levels, while Laminin is present along tracheal branches.
Title: Matrix metalloproteinase 1 modulates invasive behavior of tracheal branches during entry into Drosophila flight muscles.
there are only two MMP genes in Drosophila, DmMmp1 and DmMmp2, which makes Drosophila an attractive system to analyze the basis of MMP specificity. Previously, Drosophila MMPs have been categorized by their pericellular localization, as Mmp1 appeared to be secreted and Mmp2 appeared to be membrane-anchored, suggesting that protein localization was the critical distinction in this small MMP family
Title: Both Drosophila matrix metalloproteinases have released and membrane-tethered forms but have different substrates.
results suggest that Ubx regulates organ shape by controlling Mmp1 expression, and the extent and timing of extracellular matrix degradation.
Title: The Drosophila Hox gene Ultrabithorax controls appendage shape by regulating extracellular matrix dynamics.
This work identifies Draper-dependent activation of MMP-1 as a novel cascade required for proper glial clearance of severed axons.
Title: A novel Drosophila injury model reveals severed axons are cleared through a Draper/MMP-1 signaling cascade.
Mmp1 negatively regulates ectopic eye differentiation by restricting the rate of proliferation and the levels of expression of retinal-determining genes dachshund and eyes absent.
Title: Noncanonical Decapentaplegic Signaling Activates Matrix Metalloproteinase 1 To Restrict Hedgehog Activity and Limit Ectopic Eye Differentiation in Drosophila.
Data indicate that matrix metalloproteinases mmp1 and mmp2 mutants have distinct heart phenotypes.
Title: Matrix Metalloproteinases are required for membrane motility and lumenogenesis during Drosophila heart development.
These data demonstrate that Mmp1 modulates PDF processing, which leads to daily structural remodeling and circadian behavior.
Title: Mmp1 processing of the PDF neuropeptide regulates circadian structural plasticity of pacemaker neurons.
A primary function of Mmp1, under the control of the JNK pathway, is to promote basement membrane repair, which in turn may permit cell migration and the restoration of a continuous tissue.
Title: A secreted MMP is required for reepithelialization during wound healing.
Drosophila Mmp1 is involved in the regulation of ISC proliferation for maintenance of gut homeostasis
Title: Requirement of matrix metalloproteinase-1 for intestinal homeostasis in the adult Drosophila midgut.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adult fat body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basement membrane disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basement membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell-cell junction organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in collagen catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dorsal trunk growth, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic heart tube formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fasciculation of motor neuron axon	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc eversion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in instar larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in molting cycle, chitin-based cuticle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of tube length, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tissue regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral cord development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in dendrite	IMP Inferred from Mutant Phenotype more info	PubMed
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: matrix metalloproteinase 1

Names: CG4859-PC; CG4859-PD; CG4859-PE; CG4859-PF; CG4859-PG; CG4859-PH; CG4859-PI; CG4859-PJ; CG4859-PK; CG4859-PL; Mmp1-PC; Mmp1-PD; Mmp1-PE; Mmp1-PF; Mmp1-PG; Mmp1-PH; Mmp1-PI; Mmp1-PJ; Mmp1-PK; Mmp1-PL; extracellular matrix metalloproteinase; matrix metalloprotease; matrix metalloprotease 1; matrix metalloproteinase-1; matrix metalloproteinase1; matrix metalloprotinase 1; metalloprotease 1; metalloproteinase

NP_001188999.1

EC 3.4.24.-

NP_001189000.1

EC 3.4.24.-

NP_001189001.1

EC 3.4.24.-

NP_001189002.1

EC 3.4.24.-

NP_001189003.1

EC 3.4.24.-

NP_001189004.1

EC 3.4.24.-

NP_001189005.1

EC 3.4.24.-

NP_001246499.1

EC 3.4.24.-

NP_523852.3

EC 3.4.24.-

NP_726473.2

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

24671294..24688184 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001202074.2 → NP_001189003.1 matrix metalloproteinase 1, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189003.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4JD53, D3DMJ8

Conserved Domains (4) summary

cd00094
Location:298 → 493

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:115 → 268

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:115 → 268

Peptidase_M10; Matrixin

pfam01471
Location:32 → 88

PG_binding_1; Putative peptidoglycan binding domain
NM_001259570.2 → NP_001246499.1 matrix metalloproteinase 1, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246499.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7H5, D3DMJ8

Conserved Domains (4) summary

cd00094
Location:298 → 493

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:115 → 268

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:115 → 268

Peptidase_M10; Matrixin

pfam01471
Location:32 → 88

PG_binding_1; Putative peptidoglycan binding domain
NM_166683.2 → NP_726473.2 matrix metalloproteinase 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726473.2

Status: REVIEWED

UniProtKB/TrEMBL

B5X0I8, Q8MT35, Q9W122

Conserved Domains (4) summary

cd00094
Location:298 → 493

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:115 → 268

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:115 → 268

Peptidase_M10; Matrixin

pfam01471
Location:32 → 88

PG_binding_1; Putative peptidoglycan binding domain
NM_001202073.1 → NP_001189002.1 matrix metalloproteinase 1, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189002.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4JDA7, B5X0I8

Conserved Domains (4) summary

cd00094
Location:298 → 493

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:115 → 268

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:115 → 268

Peptidase_M10; Matrixin

pfam01471
Location:32 → 88

PG_binding_1; Putative peptidoglycan binding domain
NM_001202076.1 → NP_001189005.1 matrix metalloproteinase 1, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189005.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4JD53, D3DMJ8

Conserved Domains (4) summary

cd00094
Location:298 → 493

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:115 → 268

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:115 → 268

Peptidase_M10; Matrixin

pfam01471
Location:32 → 88

PG_binding_1; Putative peptidoglycan binding domain
NM_001202075.1 → NP_001189004.1 matrix metalloproteinase 1, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189004.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7H5, D3DMJ8

Conserved Domains (4) summary

cd00094
Location:298 → 493

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:115 → 268

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:115 → 268

Peptidase_M10; Matrixin

pfam01471
Location:32 → 88

PG_binding_1; Putative peptidoglycan binding domain
NM_001202070.1 → NP_001188999.1 matrix metalloproteinase 1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188999.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4JCU7, Q9GTK3

Conserved Domains (4) summary

cd00094
Location:298 → 493

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:115 → 268

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:115 → 268

Peptidase_M10; Matrixin

pfam01471
Location:32 → 88

PG_binding_1; Putative peptidoglycan binding domain
NM_001202072.2 → NP_001189001.1 matrix metalloproteinase 1, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189001.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MLN6, Q9GTK3

Conserved Domains (4) summary

cd00094
Location:298 → 493

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:115 → 268

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:115 → 268

Peptidase_M10; Matrixin

pfam01471
Location:32 → 88

PG_binding_1; Putative peptidoglycan binding domain
NM_079128.4 → NP_523852.3 matrix metalloproteinase 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523852.3

Status: REVIEWED

UniProtKB/TrEMBL

Q8MLN6, Q9GTK3

Conserved Domains (4) summary

cd00094
Location:298 → 493

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:115 → 268

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:115 → 268

Peptidase_M10; Matrixin

pfam01471
Location:32 → 88

PG_binding_1; Putative peptidoglycan binding domain
NM_001202071.1 → NP_001189000.1 matrix metalloproteinase 1, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189000.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MLN6, Q9GTK3

Conserved Domains (4) summary

cd00094
Location:298 → 493

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:115 → 268

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:115 → 268

Peptidase_M10; Matrixin

pfam01471
Location:32 → 88

PG_binding_1; Putative peptidoglycan binding domain

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0B4JCU7		A0A0B4JCU7
A0A0B4JD53		A0A0B4JD53
A0A0B4JDA7		A0A0B4JDA7
A0A0B4K7H5		A0A0B4K7H5
Q8MLN6		Q8MLN6
Q9GTK3		Q9GTK3
Q9W122		Q9W122