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ddit4.S DNA damage inducible transcript 4 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 379481, updated on 4-Nov-2024

Summary

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Official Symbol
ddit4.S
Official Full Name
DNA damage inducible transcript 4 S homeolog
Primary source
Xenbase:XB-GENE-944281
Locus tag
XELAEV_18037099mg
See related
EnsemblRapid:ENSXLAG00005025944 AllianceGenome:Xenbase:XB-GENE-944281
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
ddit4; redd1; enpr02
Summary
Predicted to enable 14-3-3 protein binding activity. Predicted to act upstream of or within apoptotic process; negative regulation of TOR signaling; and response to hypoxia. Predicted to be located in cytoplasm. Is expressed in cardiovascular system; ectoderm; nervous system; sensory system; and visual system. Orthologous to human DDIT4 (DNA damage inducible transcript 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ddit4.S in Genome Data Viewer
Location:
chromosome: 7S
Exon count:
3
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 7S NC_054384.1 (29996722..29999652, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 7S NC_030737.1 (28483671..28486601, complement)

Chromosome 7S - NC_054384.1Genomic Context describing neighboring genes Neighboring gene mitochondrial calcium uptake 1 S homeolog Neighboring gene DnaJ heat shock protein family (Hsp40) member B12 S homeolog Neighboring gene uncharacterized LOC121396276 Neighboring gene anaphase promoting complex subunit 16 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. Ellisen LW, et al. Mol Cell, 2002 Nov. PMID 12453409
  2. An atlas of differential gene expression during early Xenopus embryogenesis. Pollet N, et al. Mech Dev, 2005 Mar. PMID 15763213
  3. Axeldb: a Xenopus laevis database focusing on gene expression. Pollet N, et al. Nucleic Acids Res, 2000 Jan 1. PMID 10592204, Free PMC Article
  4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC64453

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables 14-3-3 protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of TOR signaling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to hypoxia IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA damage-inducible transcript 4 protein
Names
REDD-1
protein regulated in development and DNA damage response 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086322.1 → NP_001079791.1  DNA damage-inducible transcript 4 protein

    See identical proteins and their annotated locations for NP_001079791.1

    Status: PROVISIONAL

    Source sequence(s)
    BC054246
    UniProtKB/Swiss-Prot
    Q7SYV9
    UniProtKB/TrEMBL
    A0A974CBM2
    Related
    ENSXLAP00005077110.1, ENSXLAT00005078701.1
    Conserved Domains (1) summary
    pfam07809
    Location:94 → 210
    RTP801_C; RTP801 C-terminal region

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054384.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    29996722..29999652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7SYV9.1 GenPept UniProtKB/Swiss-Prot:Q7SYV9

Gene LinkOut

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