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ND-19 NADH dehydrogenase (ubiquinone) 19 kDa subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37946, updated on 18-Sep-2024

Summary

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Official Symbol
ND-19provided by FlyBase
Official Full Name
NADH dehydrogenase (ubiquinone) 19 kDa subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0035046
Locus tag
Dmel_CG3683
See related
AllianceGenome:FB:FBgn0035046
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3683; Dmel\CG3683; dNDUFA8; ND19; Ndufa8; NDUFA8; NUPM; Q9W125; RH23043p
Summary
Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be part of mitochondrial respiratory chain complex I. Is expressed in several structures, including adult heart; embryonic/larval muscle system; extended germ band embryo; gut section; and spermatozoon. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency. Orthologous to human NDUFA8 (NADH:ubiquinone oxidoreductase subunit A8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See ND-19 in Genome Data Viewer
Location:
60D13-60D13; 2-107 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24664398..24665439)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20551921..20552962)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cuticular protein 60D Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ciona intestinalis NADH dehydrogenase NDX confers stress-resistance and extended lifespan on Drosophila. Gospodaryov DV, et al. Biochim Biophys Acta, 2014 Nov. PMID 25124484
  2. Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction. Sanz A, et al. Proc Natl Acad Sci U S A, 2010 May 18. PMID 20435911, Free PMC Article
  3. Practical Recommendations for the Use of the GeneSwitch Gal4 System to Knock-Down Genes in Drosophila melanogaster. Scialo F, et al. PLoS One, 2016. PMID 27570965, Free PMC Article
  4. Aconitase causes iron toxicity in Drosophila pink1 mutants. Esposito G, et al. PLoS Genet, 2013 Apr. PMID 23637640, Free PMC Article
  5. Mitochondrial electron transport chain defects modify Parkinson's disease phenotypes in a Drosophila model. O'Hanlon ME, et al. Neurobiol Dis, 2022 Sep. PMID 35764292

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone IC
Inferred by Curator
more info
 PubMed 
involved_in mitochondrial electron transport, NADH to ubiquinone IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IC
Inferred by Curator
more info
 PubMed 
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex I IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex I ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
NADH dehydrogenase (ubiquinone) 19 kDa subunit
Names
CG3683-PA
CG3683-PB
CG3683-PC
CG3683-PD
FBpp0072231
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8
NADH ubiquinone oxidoreductase 19 kDa
NADH-UBIQUINONE OXIDOREDUCTASE 19 KDA SUBUNIT
NADH:ubiquinone oxidoreductase 19 kDa subunit
ND-19-PA
ND-19-PB
ND-19-PC
ND-19-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24664398..24665439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138110.4 → NP_611954.2  NADH dehydrogenase (ubiquinone) 19 kDa subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611954.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SY88, Q9W125
    Related
    FBpp0072231
    Conserved Domains (1) summary
    pfam06747
    Location:80 → 116
    CHCH; CHCH domain

  2. NM_166681.2 → NP_726471.1  NADH dehydrogenase (ubiquinone) 19 kDa subunit, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726471.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SY88, Q9W125
    Related
    FBpp0072233
    Conserved Domains (1) summary
    pfam06747
    Location:80 → 116
    CHCH; CHCH domain

  3. NM_166680.3 → NP_726470.1  NADH dehydrogenase (ubiquinone) 19 kDa subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726470.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SY88, Q9W125
    Related
    FBpp0072232
    Conserved Domains (1) summary
    pfam06747
    Location:80 → 116
    CHCH; CHCH domain

  4. NM_001169825.2 → NP_001163296.1  NADH dehydrogenase (ubiquinone) 19 kDa subunit, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163296.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SY88, Q9W125
    Conserved Domains (1) summary
    pfam06747
    Location:80 → 116
    CHCH; CHCH domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SY88 Q8SY88
Q9W125 Q9W125

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