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anxa1.S annexin A1 gene 1 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 379455, updated on 4-Nov-2024

Summary

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Official Symbol
anxa1.S
Official Full Name
annexin A1 gene 1 S homeolog
Primary source
Xenbase:XB-GENE-17330548
Locus tag
XELAEV_18010116mg
See related
EnsemblRapid:ENSXLAG00005003836 AllianceGenome:Xenbase:XB-GENE-17330548
Gene type
protein coding
RefSeq status
PREDICTED
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
anx1; lpc1; anxa1.1; anxa1.1.S
Summary
Predicted to enable several functions, including cadherin binding activity involved in cell-cell adhesion; calcium-dependent phospholipid binding activity; and phospholipase A2 inhibitor activity. Predicted to act upstream of or within several processes, including regulation of T cell activation; regulation of cytokine production; and regulation of vesicle-mediated transport. Predicted to be located in several cellular components, including basolateral plasma membrane; extracellular space; and lateral plasma membrane. Human ortholog(s) of this gene implicated in brain ischemia and pancreatic cancer. Orthologous to human ANXA1 (annexin A1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See anxa1.S in Genome Data Viewer
Location:
chromosome: 1S
Exon count:
13
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1S NC_054372.1 (120857501..120869741)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1S NC_030725.1 (106128268..106153466)

Chromosome 1S - NC_054372.1Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 1 family member A1 S homeolog Neighboring gene cytochrome P450 family 1 subfamily D polypeptide 1 S homeolog Neighboring gene annexin A1 gene 2 S homeolog Neighboring gene annexin A1 gene 3 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC64326

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables cadherin binding involved in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase A2 inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within alpha-beta T cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within arachidonate secretion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to glucocorticoid stimulus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to vascular endothelial growth factor stimulus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within endocrine pancreas development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within gliogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within granulocyte chemotaxis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hepatocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within insulin secretion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within myoblast migration involved in skeletal muscle regeneration IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of T-helper 2 cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of exocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neutrophil clearance IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of T-helper 1 cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of cell migration involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of interleukin-2 production IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of neutrophil apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of prostaglandin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of vesicle fusion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of wound healing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of hormone secretion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of interleukin-1 production IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of leukocyte migration IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to X-ray IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to estradiol IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to peptide hormone IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in lateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC379455
Names
annexin A1 S homeolog
lipocortin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086296.1 → NP_001079765.1  uncharacterized protein LOC379455

    See identical proteins and their annotated locations for NP_001079765.1

    Status: PREDICTED

    Source sequence(s)
    BC054187
    UniProtKB/TrEMBL
    A0A974DTX8, Q7SZ11
    Related
    ENSXLAP00005011447.1, ENSXLAT00005011621.1
    Conserved Domains (1) summary
    pfam00191
    Location:113 → 178
    Annexin; Annexin

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054372.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    120857501..120869741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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Molecular Biology Databases
Research Materials