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plp1.S proteolipid protein 1 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 379423, updated on 4-Nov-2024

Summary

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Official Symbol
plp1.S
Official Full Name
proteolipid protein 1 S homeolog
Primary source
Xenbase:XB-GENE-6255820
Locus tag
XELAEV_18041948mg
See related
EnsemblRapid:ENSXLAG00005024829 AllianceGenome:Xenbase:XB-GENE-6255820
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
PLP; pmd; hld1; mmpl; plp1; spg2; PLP-B; plp1b; plp1-a; plp1-b
Summary
Predicted to be a structural constituent of myelin sheath. Predicted to act upstream of or within axon development and central nervous system myelination. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2. Orthologous to human PLP1 (proteolipid protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See plp1.S in Genome Data Viewer
Location:
chromosome: 8S
Exon count:
9
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8S NC_054386.1 (48332947..48419405, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8S NC_030739.1 (47757089..47780276, complement)

Chromosome 8S - NC_054386.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121397697 Neighboring gene RAB9B, member RAS oncogene family S homeolog Neighboring gene zinc finger MYM-type protein 1-like Neighboring gene transfer RNA lysine (anticodon UUU)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolution of the myelin integral membrane proteins of the central nervous system. Schliess F, et al. Biol Chem Hoppe Seyler, 1991 Sep. PMID 1722981
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables structural constituent of myelin sheath IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within axon development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within central nervous system myelination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in myelin sheath IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
myelin proteolipid protein B
Names
Lipophilin-B
proteolipid protein 1 b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086265.2 → NP_001079734.1  myelin proteolipid protein B

    See identical proteins and their annotated locations for NP_001079734.1

    Status: PROVISIONAL

    Source sequence(s)
    BC053789
    UniProtKB/TrEMBL
    A0A974C367
    Related
    ENSXLAP00005073820.1, ENSXLAT00005075385.1
    Conserved Domains (1) summary
    pfam01275
    Location:3 → 265
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    48332947..48419405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041574077.1 → XP_041430011.1  myelin proteolipid protein B isoform X1

    UniProtKB/TrEMBL
    A0A8J1LL63, A0A974C367
    Conserved Domains (1) summary
    smart00002
    Location:170 → 229
    PLP; Myelin proteolipid protein (PLP or lipophilin)

  2. XM_018231841.2 → XP_018087330.1  myelin proteolipid protein B isoform X2

    UniProtKB/Swiss-Prot
    P23290, Q7SZ96
    UniProtKB/TrEMBL
    A0A8J0TKW3
    Related
    ENSXLAP00005073684.1, ENSXLAT00005075250.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23290.3 GenPept UniProtKB/Swiss-Prot:P23290

Gene LinkOut

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Research Materials