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rhoa.L ras homolog family member A L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 379416, updated on 17-Aug-2024

Summary

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Official Symbol
rhoa.L
Official Full Name
ras homolog family member A L homeolog
Primary source
Xenbase:XB-GENE-865846
Locus tag
XELAEV_18023803mg
See related
EnsemblRapid:ENSXLAG00005029893
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
arha; rhoa; xrhoa; rhoa-a; rhoa-b
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Genomic context

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Location:
chromosome: 4L
Exon count:
8
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4L NC_054377.1 (124620217..124640693, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4L NC_030730.1 (119358683..119379159, complement)

Chromosome 4L - NC_054377.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 4 L homeolog Neighboring gene glutathione peroxidase 1 L homeolog Neighboring gene aminomethyltransferase L homeolog Neighboring gene nicolin 1 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pattern formation of Rho GTPases in single cell wound healing. Simon CM, et al. Mol Biol Cell, 2013 Feb. PMID 23264464, Free PMC Article
  2. Activator-inhibitor coupling between Rho signalling and actin assembly makes the cell cortex an excitable medium. Bement WM, et al. Nat Cell Biol, 2015 Nov. PMID 26479320, Free PMC Article
  3. Involvement of the small GTPases XRhoA and XRnd1 in cell adhesion and head formation in early Xenopus development. Wünnenberg-Stapleton K, et al. Development, 1999 Dec. PMID 10556059
  4. MgcRacGAP restricts active RhoA at the cytokinetic furrow and both RhoA and Rac1 at cell-cell junctions in epithelial cells. Breznau EB, et al. Mol Biol Cell, 2015 Jul 1. PMID 25947135, Free PMC Article
  5. Transcriptional regulation of blood vessel formation: the role of the CASZ1/Egfl7/RhoA pathway. Charpentier MS, et al. Cell Cycle, 2013 Jul 15. PMID 23803731, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mgc's GAP activity down-regulates the active populations of RhoA and Rac1 at localized regions of epithelial cells and is necessary for successful cytokinesis and cell-cell junction structure
    Title: MgcRacGAP restricts active RhoA at the cytokinetic furrow and both RhoA and Rac1 at cell-cell junctions in epithelial cells.
  2. Data show that shortly after anaphase onset oocytes and embryonic cells exhibit cortical waves of Rho activity and F-actin polymerization.
    Title: Activator-inhibitor coupling between Rho signalling and actin assembly makes the cell cortex an excitable medium.
  3. CASZ1/Egfl7/RhoA pathway is necessary for promoting endothelial cell behaviors associated with proper vascular assembly.
    Title: Transcriptional regulation of blood vessel formation: the role of the CASZ1/Egfl7/RhoA pathway.
  4. RhoA can be considered a component of the intracellular pattern formation system.
    Title: Pattern formation of Rho GTPases in single cell wound healing.
  5. Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity.
    Title: Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity.
  6. Morphogenesis of the primitive gut tube is generated by Rho/ROCK/myosin II-mediated endoderm rearrangements.
    Title: Morphogenesis of the primitive gut tube is generated by Rho/ROCK/myosin II-mediated endoderm rearrangements.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC64296

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within contact inhibition IC
Inferred by Curator
more info
 PubMed 
acts_upstream_of_or_within_negative_effect neuron development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skeletal muscle satellite cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within stress fiber assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within swimming behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within wound healing, spreading of cells ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cleavage furrow IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras homolog family member A L homeolog
Names
ras homolog gene family, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086260.2 → NP_001079729.1  ras homolog family member A L homeolog

    See identical proteins and their annotated locations for NP_001079729.1

    Status: PROVISIONAL

    Source sequence(s)
    BC053772
    UniProtKB/TrEMBL
    A0A974D7K4, Q7SZA9, Q8JHE2
    Related
    ENSXLAP00005089413.1, ENSXLAT00005091082.1
    Conserved Domains (1) summary
    cd01870
    Location:5 → 179
    RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    124620217..124640693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018256447.2 → XP_018111936.1  ras homolog family member A L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A974D7K4, Q7SZA9, Q8JHE2
    Related
    ENSXLAP00005089363.1, ENSXLAT00005091032.1
    Conserved Domains (1) summary
    cd01870
    Location:5 → 179
    RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC

  2. XM_018256445.1 → XP_018111934.1  ras homolog family member A L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A974D7K4, Q7SZA9, Q8JHE2
    Related
    ENSXLAP00005089495.1, ENSXLAT00005091163.1
    Conserved Domains (1) summary
    cd01870
    Location:5 → 179
    RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC

  3. XM_018256446.1 → XP_018111935.1  ras homolog family member A L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A974D7K4, Q7SZA9, Q8JHE2
    Conserved Domains (1) summary
    cd01870
    Location:5 → 179
    RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC

  4. XM_018256448.2 → XP_018111937.1  ras homolog family member A L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A974D7K4, Q7SZA9, Q8JHE2
    Conserved Domains (1) summary
    cd01870
    Location:5 → 179
    RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
Nucleotide Protein Strain
Heading Accession and Version

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