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psmc3.S proteasome 26S subunit, ATPase 3 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 379370, updated on 4-Nov-2024

Summary

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Official Symbol
psmc3.S
Official Full Name
proteasome 26S subunit, ATPase 3 S homeolog
Primary source
Xenbase:XB-GENE-1009853
Locus tag
XELAEV_18024434mg
See related
EnsemblRapid:ENSXLAG00005019457 AllianceGenome:Xenbase:XB-GENE-1009853
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
psmc3; tbp10; XTBP10; psmc3-b
Summary
Predicted to enable ATP binding activity; ATP hydrolysis activity; and proteasome-activating activity. Predicted to act upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of proteasome accessory complex. Orthologous to human PSMC3 (proteasome 26S subunit, ATPase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See psmc3.S in Genome Data Viewer
Location:
chromosome: 4S
Exon count:
12
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4S NC_054378.1 (12054975..12066685)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4S NC_030731.1 (11783075..11794903)

Chromosome 4S - NC_054378.1Genomic Context describing neighboring genes Neighboring gene mitochondrial carrier 2 S homeolog Neighboring gene uncharacterized LOC121393453 Neighboring gene serine/threonine-protein kinase mig-15-like Neighboring gene traf2 and NCK-interacting protein kinase-like Neighboring gene transmembrane protein 178B Neighboring gene solute carrier family 39 (zinc transporter), member 13 S homeolog Neighboring gene protein kinase C delta type-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Members of the AAA-gene family are involved in early embryogenesis of vertebrates. Nacken W. Biochim Biophys Acta, 1997 Oct 9. PMID 9375782
  2. Wnt signalling regulates paxillin ubiquitination essential for mesodermal cell motility. Iioka H, et al. Nat Cell Biol, 2007 Jul. PMID 17558393
  3. The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5. Miyashita R, et al. Elife, 2023 Feb 3. PMID 36734974, Free PMC Article
  4. Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation. Nishiyama A, et al. Nat Commun, 2020 Mar 6. PMID 32144273, Free PMC Article
  5. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC53343

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables proteasome-activating activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome accessory complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome regulatory particle, base subcomplex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
26S proteasome regulatory subunit 6A-B
Names
26S protease regulatory subunit 6A-B
26S proteasome AAA-ATPase subunit RPT5-B
TAT-binding protein 10
TBP-10
proteasome (prosome, macropain) 26S subunit, ATPase, 3
proteasome 26S subunit ATPase 3-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086214.1 → NP_001079683.1  26S proteasome regulatory subunit 6A-B

    See identical proteins and their annotated locations for NP_001079683.1

    Status: PROVISIONAL

    Source sequence(s)
    BC046948
    UniProtKB/Swiss-Prot
    O42586
    UniProtKB/TrEMBL
    A0A974CXS7, Q7ZWL9
    Related
    ENSXLAP00005057225.1, ENSXLAT00005058572.1
    Conserved Domains (1) summary
    COG1222
    Location:28 → 416
    RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054378.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    12054975..12066685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041591157.1 → XP_041447091.1  26S proteasome regulatory subunit 6A-B isoform X1

    UniProtKB/Swiss-Prot
    O42586
    UniProtKB/TrEMBL
    A0A974CXS7, Q7ZWL9
    Related
    ENSXLAP00005057161.1, ENSXLAT00005058509.1
    Conserved Domains (1) summary
    COG1222
    Location:28 → 416
    RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]

  2. XM_041591158.1 → XP_041447092.1  26S proteasome regulatory subunit 6A-B isoform X1

    UniProtKB/Swiss-Prot
    O42586
    UniProtKB/TrEMBL
    A0A974CXS7, Q7ZWL9
    Conserved Domains (1) summary
    COG1222
    Location:28 → 416
    RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O42586.1 GenPept UniProtKB/Swiss-Prot:O42586

Gene LinkOut

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