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hspa8.L heat shock protein family A (Hsp70) member 8 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 379319, updated on 4-Nov-2024

Summary

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Official Symbol
hspa8.L
Official Full Name
heat shock protein family A (Hsp70) member 8 L homeolog
Primary source
Xenbase:XB-GENE-955429
Locus tag
XELAEV_18035213mg
See related
EnsemblRapid:ENSXLAG00005031957 AllianceGenome:Xenbase:XB-GENE-955429
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
lap1; hsc54; hsc70; hsc71; hsp71; hsp73; hspa8; nip71; hspa10; hsc70.II
Summary
Predicted to enable ATP binding activity; ATP-dependent protein folding chaperone; and clathrin-uncoating ATPase activity. Predicted to act upstream of or within several processes, including late endosomal microautophagy; protein targeting to lysosome involved in chaperone-mediated autophagy; and protein-containing complex disassembly. Predicted to be located in several cellular components, including postsynaptic cytosol; presynaptic cytosol; and vacuole. Human ortholog(s) of this gene implicated in Parkinson's disease and renal hypertension. Orthologous to human HSPA8 (heat shock protein family A (Hsp70) member 8). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hspa8.L in Genome Data Viewer
Location:
chromosome: 7L
Exon count:
9
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 7L NC_054383.1 (68451620..68457977, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 7L NC_030736.1 (59981703..59987693, complement)

Chromosome 7L - NC_054383.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121395525 Neighboring gene migration and invasion inhibitory protein L homeolog Neighboring gene small nucleolar RNA SNORD14 Neighboring gene small nucleolar RNA SNORD14 Neighboring gene small nucleolar RNA SNORD14 Neighboring gene CXADR-like membrane protein L homeolog Neighboring gene GRAM domain containing 1B L homeolog Neighboring gene uncharacterized LOC121395526

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hsp72 mediates stronger antigen-dependent non-classical MHC class Ib anti-tumor responses than hsc73 in Xenopus laevis. Nedelkovska H, et al. Cancer Immun, 2013. PMID 23390375, Free PMC Article
  2. Molecular cloning of a cDNA encoding a Xenopus laevis 70-kDa heat shock cognate protein, hsc70.II. Ali A, et al. Biochim Biophys Acta, 1996 Dec 11. PMID 8982250
  3. The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5. Miyashita R, et al. Elife, 2023 Feb 3. PMID 36734974, Free PMC Article
  4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. hsp72 was more potent than hsc73 in generating protective immune responses against the class Ia-negative 15/0 tumors.
    Title: Hsp72 mediates stronger antigen-dependent non-classical MHC class Ib anti-tumor responses than hsc73 in Xenopus laevis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC53952

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables clathrin-uncoating ATPase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chaperone-mediated autophagy translocation complex disassembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within clathrin coat disassembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within late endosomal microautophagy IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein targeting to lysosome involved in chaperone-mediated autophagy IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within slow axonal transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in autophagosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in presynaptic cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in terminal bouton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
heat shock protein family A (Hsp70) member 8 L homeolog
Names
heat shock 70kDa protein 8
heat shock cognate 70.II protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086163.1 → NP_001079632.1  heat shock protein family A (Hsp70) member 8 L homeolog

    See identical proteins and their annotated locations for NP_001079632.1

    Status: PROVISIONAL

    Source sequence(s)
    BC046262
    UniProtKB/TrEMBL
    A0A974HBW2, Q7ZTK6
    Related
    ENSXLAP00005096341.1, ENSXLAT00005098116.1
    Conserved Domains (2) summary
    cd10233
    Location:6 → 381
    HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
    PTZ00009
    Location:1 → 612
    PTZ00009; heat shock 70 kDa protein; Provisional

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054383.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    68451620..68457977 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041568355.1 → XP_041424289.1  heat shock protein family A (Hsp70) member 8 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J1L5Q7, A0A974HBW2
    Related
    ENSXLAP00005096161.1, ENSXLAT00005097928.1
    Conserved Domains (1) summary
    PTZ00009
    Location:1 → 561
    PTZ00009; heat shock 70 kDa protein; Provisional
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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