mturn.S maturin, neural progenitor differentiation regulator homolog (Xenopus) S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: mturn.S
Official Full Name: maturin, neural progenitor differentiation regulator homolog (Xenopus) S homeolog
Primary source: Xenbase:XB-GENE-945490
Locus tag: XELAEV_18033173mg
See related: EnsemblRapid:ENSXLAG00005021080 AllianceGenome:Xenbase:XB-GENE-945490
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: mturn; c7orf41; mturn.L
Summary: Acts upstream of or within several processes, including negative regulation of neuroblast proliferation; neural plate formation; and positive regulation of neuron differentiation. Predicted to be located in cytoplasm. Is expressed in ectoderm; nervous system; vestibuloauditory system; and visual system. Orthologous to human MTURN (maturin, neural progenitor differentiation regulator homolog). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 6S

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	6S	NC_054382.1 (44159822..44168874, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	6S	NC_030735.1 (43076387..43085440, complement)

Chromosome 6S - NC_054382.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Maturin knockdown and overexpression studies showed that it is required for primary neurogenesis and regulates neural differentiation.
Title: Maturin is a novel protein required for differentiation during primary neurogenesis.
Maturin functions during primary neurogenesis and is required for the proneural pathway to regulate neural differentiation.
Title: Maturin is a novel protein required for differentiation during primary neurogenesis.

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General gene information

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Gene Ontology Provided by Xenbase

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural plate formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of megakaryocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of megakaryocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of signaling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: maturin

Names: UPF0452 protein C7orf41 homolog; maturin neural progenitor differentiation regulator protein; maturin, neural progenitor differentiation regulator homolog L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086157.1 → NP_001079626.1 maturin

See identical proteins and their annotated locations for NP_001079626.1

Status: PROVISIONAL

Source sequence(s)

BC045253

UniProtKB/Swiss-Prot

Q6GQZ4, Q7ZX36

Related

ENSXLAP00005061838.1, ENSXLAT00005063291.1

Conserved Domains (1) summary

pfam15167
Location:4 → 131

DUF4581; Domain of unknown function (DUF4581)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054382.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

44159822..44168874 complement

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GenBank, FASTA, Sequence Viewer (Graphics)