ppp2r2d.S protein phosphatase 2 regulatory subunit B, delta S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: ppp2r2d.S
Official Full Name: protein phosphatase 2 regulatory subunit B, delta S homeolog
Primary source: Xenbase:XB-GENE-940318
Locus tag: XELAEV_18036860mg
See related: EnsemblRapid:ENSXLAG00005011734
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: ppp2r2d; ppp2r2d.L
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 7S

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	7S	NC_054384.1 (12366314..12387431, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	7S	NC_030737.1 (12359856..12380832, complement)

Chromosome 7S - NC_054384.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of CaMKII depends, in part, on dephosphorylation of CaMKII mediated by metabolic activation of protein phosphatase 2A in complex with the B55beta targeting subunit.
Title: Metabolic control of Ca2+/calmodulin-dependent protein kinase II (CaMKII)-mediated caspase-2 suppression by the B55β/protein phosphatase 2A (PP2A).
a previously undescribed role for the Greatwall-PP2A:B55delta interaction in creating a toggle switch for activation of the anaphase-promoting complex as embryonic cells exit mitosis and return to interphase.
Title: Role for regulated phosphatase activity in generating mitotic oscillations in Xenopus cell-free extracts.
[review] PP2A-B55delta is the major phosphatase controlling exit from mitosis; it is negatively regulated by the kinase Greatwall that phosphorylates the small protein ARPP-19 and converts it into a potent protein phosphatase 2A inhibitor.
Title: Greatwall kinase, ARPP-19 and protein phosphatase 2A: shifting the mitosis paradigm.
These highly related members of the same subfamily of PP2A regulatory subunits differentially regulate TGF-beta/Activin/Nodal signalling to elicit opposing biological outcomes.
Title: Two highly related regulatory subunits of PP2A exert opposite effects on TGF-beta/Activin/Nodal signalling.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase regulator activity	IEA Inferred from Electronic Annotation more info
enables protein phosphatase regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
part_of protein phosphatase type 2A complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein phosphatase type 2A complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

Names: protein phosphatase 2 regulatory subunit B, delta L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086149.1 → NP_001079618.1 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

See identical proteins and their annotated locations for NP_001079618.1

Status: PROVISIONAL

Source sequence(s)

BC045219

UniProtKB/Swiss-Prot

Q7ZX64

UniProtKB/TrEMBL

A0A974H9M5

Related

ENSXLAP00005034345.1, ENSXLAT00005035228.1

Conserved Domains (3) summary

COG5170
Location:7 → 442

CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]

sd00039
Location:31 → 79

7WD40; WD40 repeat [structural motif]

cl02567
Location:176 → 438

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054384.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

12366314..12387431 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)