far1.L fatty acyl-CoA reductase 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: far1.L
Official Full Name: fatty acyl-CoA reductase 1 L homeolog
Primary source: Xenbase:XB-GENE-973782
Locus tag: XELAEV_18021931mg
See related: EnsemblRapid:ENSXLAG00005022323 AllianceGenome:Xenbase:XB-GENE-973782
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: far1; mlstd2
Summary: Predicted to enable alcohol-forming long-chain fatty acyl-CoA reductase activity. Predicted to act upstream of or within ether lipid biosynthetic process and wax biosynthetic process. Predicted to be located in peroxisomal membrane. Human ortholog(s) of this gene implicated in rhizomelic chondrodysplasia punctate type 4. Orthologous to human FAR1 (fatty acyl-CoA reductase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 4L

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4L	NC_054377.1 (11920327..11981186, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4L	NC_030730.1 (11390056..11450982, complement)

Chromosome 4L - NC_054377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables alcohol-forming long-chain fatty acyl-CoA reductase activity	IEA Inferred from Electronic Annotation more info
enables alcohol-forming long-chain fatty acyl-CoA reductase activity	ISS Inferred from Sequence or Structural Similarity more info
enables alcohol-forming very long-chain fatty acyl-CoA reductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ether lipid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within fatty acid derivative metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within long-chain fatty-acyl-CoA metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within wax biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fatty acyl-CoA reductase 1

Names: fatty acyl CoA reductase 1; male sterility domain-containing protein 2

NP_001079591.1

EC 1.2.1.84

XP_018111925.1

EC 1.2.1.84

XP_041445066.1

EC 1.2.1.84

XP_041445067.1

EC 1.2.1.84

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086122.1 → NP_001079591.1 fatty acyl-CoA reductase 1

See identical proteins and their annotated locations for NP_001079591.1

Status: PROVISIONAL

Source sequence(s)

BC045017

UniProtKB/Swiss-Prot

Q7ZXF5

UniProtKB/TrEMBL

A0A974HMP9

Related

ENSXLAP00005065740.1, ENSXLAT00005067255.1

Conserved Domains (3) summary

cd05236
Location:11 → 330

FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs

PLN02996
Location:3 → 446

PLN02996; fatty acyl-CoA reductase

pfam03015
Location:357 → 447

Sterile; Male sterility protein

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

11920327..11981186 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041589132.1 → XP_041445066.1 fatty acyl-CoA reductase 1 isoform X2

UniProtKB/TrEMBL

A0A8J1MUC8

Related

ENSXLAP00005065721.1, ENSXLAT00005067239.1

Conserved Domains (2) summary

cd09071
Location:358 → 449

FAR_C; C-terminal domain of fatty acyl CoA reductases

cd05236
Location:11 → 333

FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
XM_041589133.1 → XP_041445067.1 fatty acyl-CoA reductase 1 isoform X3

UniProtKB/TrEMBL

A0A8J1MTH3

Conserved Domains (2) summary

cd09071
Location:355 → 446

FAR_C; C-terminal domain of fatty acyl CoA reductases

cd05236
Location:11 → 330

FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
XM_018256436.2 → XP_018111925.1 fatty acyl-CoA reductase 1 isoform X1

UniProtKB/TrEMBL

A0A8J0USK5

Related

ENSXLAP00005065706.1, ENSXLAT00005067222.1