nsmce2.L NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligasee L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: nsmce2.L
Official Full Name: NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligasee L homeolog
Primary source: Xenbase:XB-GENE-6256344
Locus tag: XELAEV_18032356mg
See related: EnsemblRapid:ENSXLAG00005008429 AllianceGenome:Xenbase:XB-GENE-6256344
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: nse2; mms21; nsmce2
Summary: Predicted to enable SUMO transferase activity. Predicted to act upstream of or within DNA recombination; cellular senescence; and positive regulation of cell cycle process. Predicted to be located in PML body and chromosome, telomeric region. Predicted to be part of Smc5-Smc6 complex. Human ortholog(s) of this gene implicated in Seckel syndrome 10. Orthologous to human NSMCE2 (NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 6L

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	6L	NC_054381.1 (151481403..151634353)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	6L	NC_030734.1 (142318988..142472393)

Chromosome 6L - NC_054381.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables SUMO ligase activity	IEA Inferred from Electronic Annotation more info
enables SUMO transferase activity	IEA Inferred from Electronic Annotation more info
enables SUMO transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA recombination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular senescence	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of maintenance of mitotic sister chromatid cohesion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of mitotic metaphase/anaphase transition	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein sumoylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within telomere maintenance via recombination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in PML body	ISS Inferred from Sequence or Structural Similarity more info
part_of Smc5-Smc6 complex	IEA Inferred from Electronic Annotation more info
part_of Smc5-Smc6 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 SUMO-protein ligase NSE2

Names: E3 SUMO-protein transferase NSE2; MMS21 homolog; NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase L homeolog; non-SMC element 2 homolog; non-structural maintenance of chromosomes element 2 homolog

NP_001079585.1

EC 2.3.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.