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app.S amyloid beta precursor protein S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 379251, updated on 4-Nov-2024

Summary

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Official Symbol
app.S
Official Full Name
amyloid beta precursor protein S homeolog
Primary source
Xenbase:XB-GENE-17345003
Locus tag
XELAEV_18014267mg
See related
EnsemblRapid:ENSXLAG00005019602 AllianceGenome:Xenbase:XB-GENE-17345003
Gene type
protein coding
RefSeq status
PREDICTED
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Summary
Predicted to enable several functions, including heparin binding activity; serine-type endopeptidase inhibitor activity; and transition metal ion binding activity. Predicted to act upstream of or within axonogenesis; central nervous system development; and negative regulation of peptidase activity. Predicted to be located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and membrane raft. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease (multiple); cognitive disorder; traumatic brain injury; and visual epilepsy. Orthologous to human APP (amyloid beta precursor protein). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
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Genomic context

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See app.S in Genome Data Viewer
Location:
chromosome: 2S
Exon count:
16
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2S NC_054374.1 (16800553..16933427, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2S NC_030727.1 (16731020..16864247, complement)

Chromosome 2S - NC_054374.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108709216 Neighboring gene GA binding protein transcription factor subunit alpha S homeolog Neighboring gene cysteine and tyrosine-rich 1 S homeolog Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 1 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of the gene encoding the beta-amyloid precursor protein APP in Xenopus laevis. van den Hurk WH, et al. Brain Res Mol Brain Res, 2001 Dec 16. PMID 11744158
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC52816

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables heparin binding IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor activator activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables transition metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within axonogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within central nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi-associated vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC379251
Names
amyloid beta (A4) precursor protein S homeolog
beta-amyloid precursor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086095.1 → NP_001079564.1  uncharacterized protein LOC379251 precursor

    See identical proteins and their annotated locations for NP_001079564.1

    Status: PREDICTED

    Source sequence(s)
    AJ298151
    UniProtKB/TrEMBL
    A0A974HUW9, Q7ZXQ0, Q98SF9
    Related
    ENSXLAP00005058198.1, ENSXLAT00005059555.1
    Conserved Domains (6) summary
    smart00006
    Location:23 → 187
    A4_EXTRA; amyloid A4
    pfam02177
    Location:30 → 130
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam03494
    Location:601 → 638
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:641 → 691
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:132 → 187
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:291 → 473
    APP_E2; E2 domain of amyloid precursor protein

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054374.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    16800553..16933427 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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