eftud2.S elongation factor Tu GTP binding domain containing 2 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: eftud2.S
Official Full Name: elongation factor Tu GTP binding domain containing 2 S homeolog
Primary source: Xenbase:XB-GENE-972651
Locus tag: XELAEV_18046067mg
See related: EnsemblRapid:ENSXLAG00005034960 AllianceGenome:Xenbase:XB-GENE-972651
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: eftud2; snu114; snrp116
Summary: Predicted to enable GTP binding activity; GTPase activity; and nucleic acid binding activity. Predicted to act upstream of or within mRNA splicing, via spliceosome and translational elongation. Predicted to be located in cytosol and nucleus. Predicted to be part of U2-type catalytic step 2 spliceosome and U4/U6 x U5 tri-snRNP complex. Human ortholog(s) of this gene implicated in esophageal atresia; hepatitis B; hepatocellular carcinoma; mandibulofacial dysostosis, Guion-Almeida type; and microcephaly. Orthologous to human EFTUD2 (elongation factor Tu GTP binding domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 9_10S

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10S	NC_054388.1 (5278909..5301741, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10S	NC_030741.1 (5139978..5162811, complement)

Chromosome 9_10S - NC_054388.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables U5 snRNA binding	IEA Inferred from Electronic Annotation more info
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translational elongation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of U2-type catalytic step 2 spliceosome	IEA Inferred from Electronic Annotation more info
part_of U4/U6 x U5 tri-snRNP complex	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: elongation factor Tu GTP binding domain containing 2 S homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086067.1 → NP_001079536.1 elongation factor Tu GTP binding domain containing 2 S homeolog

See identical proteins and their annotated locations for NP_001079536.1

Status: PROVISIONAL

Source sequence(s)

BC044041

UniProtKB/TrEMBL

A0A974H097, Q7ZXZ9

Related

ENSXLAP00005106017.1, ENSXLAT00005108088.1

Conserved Domains (7) summary

cd04167
Location:132 → 330

Snu114p; Snu114p, a spliceosome protein, is a GTPase

cd01683
Location:659 → 836

EF2_IV_snRNP; EF-2_domain IV_snRNP domain is a part of 116kD U5-specific protein of the U5 small nucleoprotein (snRNP) particle, essential component of the spliceosome. The protein is structurally closely related to the eukaryotic translational elongation factor EF2. ...

cd04098
Location:831 → 910

eEF2_C_snRNP; eEF2_C_snRNP: This family includes a C-terminal portion of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart Snu114p. This domain is homologous to the C-terminal domain of the ...

PTZ00416
Location:124 → 956

PTZ00416; elongation factor 2; Provisional

pfam16004
Location:4 → 112

EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component N-terminus

cd04090
Location:476 → 569

EF2_II_snRNP; Domain II of the spliceosomal 116kD U5 small nuclear ribonucleoprotein (snRNP) component

cd16264
Location:588 → 659

snRNP_III; Domain III of the spliceosomal 116kD U5 small nuclear ribonucleoprotein (snRNP) component