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mst1.L macrophage stimulating 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 379214, updated on 4-Nov-2024

Summary

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Official Symbol
mst1.L
Official Full Name
macrophage stimulating 1 L homeolog
Primary source
Xenbase:XB-GENE-865755
Locus tag
XELAEV_18023809mg
See related
EnsemblRapid:ENSXLAG00005030011 AllianceGenome:Xenbase:XB-GENE-865755
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
E1A; XHL; hlp; msp; Xhlp; hgfl; mst1; nf15s2; d3f15s2; dnf15s2; livertine
Summary
Predicted to enable receptor tyrosine kinase binding activity and serine-type endopeptidase activity. Predicted to act upstream of or within proteolysis and regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular space. Is expressed in ectoderm. Orthologous to human MST1 (macrophage stimulating 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mst1.L in Genome Data Viewer
Location:
chromosome: 4L
Exon count:
19
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4L NC_054377.1 (124717769..124741455, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4L NC_030730.1 (119456645..119480564, complement)

Chromosome 4L - NC_054377.1Genomic Context describing neighboring genes Neighboring gene acylaminoacyl-peptide hydrolase L homeolog Neighboring gene T cell leukemia translocation altered L homeolog Neighboring gene ring finger protein 123 L homeolog Neighboring gene adhesion molecule with Ig-like domain 3 L homeolog Neighboring gene GDP-mannose pyrophosphorylase B L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Xenopus homologue of hepatocyte growth factor-like protein is specifically expressed in the presumptive neural plate during gastrulation. Aberger F, et al. Mech Dev, 1996 Jan. PMID 8808403
  2. Gene expression screening in Xenopus identifies molecular pathways, predicts gene function and provides a global view of embryonic patterning. Gawantka V, et al. Mech Dev, 1998 Oct. PMID 9831640
  3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC54016

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
macrophage stimulating 1 L homeolog
Names
12S E1A
macrophage stimulating 1 (hepatocyte growth factor-like)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086058.1 → NP_001079527.1  macrophage stimulating 1 L homeolog precursor

    See identical proteins and their annotated locations for NP_001079527.1

    Status: PROVISIONAL

    Source sequence(s)
    Y08734
    UniProtKB/TrEMBL
    A0A974HPE9, P70006, Q7ZTN9
    Related
    ENSXLAP00005089777.1, ENSXLAT00005091452.1
    Conserved Domains (4) summary
    smart00020
    Location:486 → 710
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:117 → 197
    KR; Kringle domain
    cd00190
    Location:487 → 713
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cd01099
    Location:35 → 113
    PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    124717769..124741455 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018256427.2 → XP_018111916.1  macrophage stimulating 1 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A1L8GP52, A0A974HPW6, Q7ZTN9
    Related
    ENSXLAP00005089903.1, ENSXLAT00005091578.1
Nucleotide Protein Strain
Heading Accession and Version

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