nek2.S NIMA-related kinase 2 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: nek2.S
Official Full Name: NIMA-related kinase 2 S homeolog
Primary source: Xenbase:XB-GENE-962781
Locus tag: XELAEV_18028702mg
See related: EnsemblRapid:ENSXLAG00005002266
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: nek2; nlk1; nek2a
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Genomic context

Location:: chromosome: 5S

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5S	NC_054380.1 (17598527..17611015)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5S	NC_030733.1 (17643993..17656218)

Chromosome 5S - NC_054380.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overall these results outline a novel, kinase independent role of Nlk1, wherein Nlk1 regulates PAPC stabilization and thereby controls gastrulation movements and Wnt/PCP signaling during development
Title: Nemo-like kinase 1 (Nlk1) and paraxial protocadherin (PAPC) cooperatively control Xenopus gastrulation through regulation of Wnt/planar cell polarity (PCP) signaling.
Nek2 is a switch balancing ciliogenesis and resorption in the development of LR asymmetry
Title: The NIMA-like kinase Nek2 is a key switch balancing cilia biogenesis and resorption in the development of left-right asymmetry.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NIMA-related kinase 2 S homeolog

Names: NIMA (never in mitosis gene a)-related kinase 2

NP_001079490.1

EC 2.7.11.1

XP_041419828.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086021.1 → NP_001079490.1 NIMA-related kinase 2 S homeolog

See identical proteins and their annotated locations for NP_001079490.1

Status: PROVISIONAL

Source sequence(s)

BC043822

UniProtKB/TrEMBL

A0A974CS32, Q7ZYE3, Q9W622

Related

ENSXLAP00005006836.1, ENSXLAT00005006945.1

Conserved Domains (2) summary

smart00220
Location:8 → 268

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd08217
Location:7 → 271

STKc_Nek2; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054380.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

17598527..17611015

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041563894.1 → XP_041419828.1 NIMA-related kinase 2 S homeolog isoform X1

UniProtKB/TrEMBL

A0A974CS32, Q9W622, Q9W623

Conserved Domains (1) summary

cd08217
Location:7 → 271

STKc_Nek2; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2