cdc42.L cell division cycle 42 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: cdc42.L
Official Full Name: cell division cycle 42 L homeolog
Primary source: Xenbase:XB-GENE-6251832
Locus tag: XELAEV_18035684mg
See related: EnsemblRapid:ENSXLAG00005016118 AllianceGenome:Xenbase:XB-GENE-6251832
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: cdc42; Xcdc42
Summary: Predicted to enable G protein activity; GTP binding activity; and protein kinase binding activity. Acts upstream of or within with a positive effect on neuron development. Acts upstream of or within swimming behavior. Predicted to be located in several cellular components, including dendritic spine; midbody; and plasma membrane. Is expressed in anatomical system; mesenchyme; and primary germ layer. Human ortholog(s) of this gene implicated in fibrosarcoma. Orthologous to human CDC42 (cell division cycle 42). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 7L

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	7L	NC_054383.1 (98334633..98356464, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	7L	NC_030736.1 (88486963..88508767, complement)

Chromosome 7L - NC_054383.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This suggests that TOCA1 binding to Cdc42 is an early step in the Cdc42-dependent pathways that govern actin dynamics, and the differential binding affinities of the effectors facilitate a handover from TOCA1 to N-WASP, which can then drive recruitment of the actin-modifying machinery.
Title: Investigation of the Interaction between Cdc42 and Its Effector TOCA1: HANDOVER OF Cdc42 TO THE ACTIN REGULATOR N-WASP IS FACILITATED BY DIFFERENTIAL BINDING AFFINITIES.
The small GTPase Cdc42 promotes membrane protrusion during polar body emission via ARP2-nucleated actin polymerization.
Title: The small GTPase Cdc42 promotes membrane protrusion during polar body emission via ARP2-nucleated actin polymerization.
these data indicate that the ITSN2 exchange factor regulates the activity of Cdc42 during embryo development affecting actin cytoskeleton in Xenopus embryos.
Title: Intersectin 2 nucleotide exchange factor regulates Cdc42 activity during Xenopus early development.
In vivo imaging reveals a role for Cdc42 in spindle positioning and planar orientation of cell divisions during vertebrate neural tube closure.
Title: In vivo imaging reveals a role for Cdc42 in spindle positioning and planar orientation of cell divisions during vertebrate neural tube closure.
Data show that in Xenopus laevis oocytes, polar body emission requires a RhoA contractile ring and Cdc42-mediated membrane protrusion.
Title: Polar body emission requires a RhoA contractile ring and Cdc42-mediated membrane protrusion.
These results demonstrate that to participate in the control of the actin cytoskeleton, RLIP needs its complete N-terminal region coding for the mu2BD and the GAP domain.
Title: Recruitment of Cdc42 through the GAP domain of RLIP participates in remodeling of the actin cytoskeleton and is involved in Xenopus gastrulation.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Cdc42 protein signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment or maintenance of cell polarity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within modification of synaptic structure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_positive_effect neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cellular component organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of filopodium assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within swimming behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cell division cycle 42 L homeolog

Names: cell division cycle 42 (GTP binding protein, 25kDa)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085899.1 → NP_001079368.1 cell division cycle 42 L homeolog

See identical proteins and their annotated locations for NP_001079368.1

Status: PROVISIONAL

Source sequence(s)

AF275252

UniProtKB/TrEMBL

Q9DDV6

Related

ENSXLAP00005047443.1, ENSXLAT00005048547.1

Conserved Domains (1) summary

cd01874
Location:3 → 177

Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054383.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

98334633..98356464 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_018224257.2 → XP_018079746.1 cell division cycle 42 L homeolog isoform X2

UniProtKB/TrEMBL

Q9DDV6

Conserved Domains (1) summary

cd01874
Location:3 → 177

Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
XM_018224256.2 → XP_018079745.1 cell division cycle 42 L homeolog isoform X2

UniProtKB/TrEMBL

Q9DDV6

Conserved Domains (1) summary

cd01874
Location:3 → 177

Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
XM_041568351.1 → XP_041424285.1 cell division cycle 42 L homeolog isoform X2

UniProtKB/TrEMBL

Q9DDV6

Conserved Domains (1) summary

cd01874
Location:3 → 177

Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
XM_018224255.1 → XP_018079744.1 cell division cycle 42 L homeolog isoform X1

UniProtKB/TrEMBL

A0A1L8FGB8, A0A974CID9

Related

ENSXLAP00005047429.1, ENSXLAT00005048533.1

Conserved Domains (1) summary

cd01874
Location:3 → 177

Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
XM_018224258.2 → XP_018079747.1 cell division cycle 42 L homeolog isoform X1

UniProtKB/TrEMBL

A0A1L8FGB8, A0A974CID9

Conserved Domains (1) summary

cd01874
Location:3 → 177

Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family