myod1.S myogenic differentiation 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: myod1.S
Official Full Name: myogenic differentiation 1 S homeolog
Primary source: Xenbase:XB-GENE-1017506
Locus tag: XELAEV_18024659mg
See related: EnsemblRapid:ENSXLAG00005004398 AllianceGenome:Xenbase:XB-GENE-1017506
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: mf1; mf25; myod; XMyoD; myod1; XtmyoD; myod1-a; myod1-b
Summary: Predicted to enable DNA-binding transcription activator activity; E-box binding activity; and promoter-specific chromatin binding activity. Acts upstream of or within cellular response to fibroblast growth factor stimulus. Predicted to be located in nucleus. Is expressed in mesoderm; musculoskeletal system; and pharyngeal arch. Human ortholog(s) of this gene implicated in congenital myopathy 17. Orthologous to human MYOD1 (myogenic differentiation 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 4S

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4S	NC_054378.1 (23265125..23267706, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4S	NC_030731.1 (22714812..22717393, complement)

Chromosome 4S - NC_054378.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a role for MyoD in the early mesoderm in regulating a set of genes that are essential for both myogenesis and somitogenesis.
Title: Early transcriptional targets of MyoD link myogenesis and somitogenesis.
MYOD can upregulate the expression of ebf genes, indicating the presence of a positive feedback loop between EBF and MYOD.
Title: EBF proteins participate in transcriptional regulation of Xenopus muscle development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables E-box binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to estradiol stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to fibroblast growth factor stimulus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within muscle organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of myoblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of skeletal muscle fiber development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of snRNA transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle cell differentiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: myoblast determination protein 1 homolog A

Names: myogenic factor 1; myogenic factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085897.1 → NP_001079366.1 myoblast determination protein 1 homolog A

See identical proteins and their annotated locations for NP_001079366.1

Status: PROVISIONAL

Source sequence(s)

BC041190

UniProtKB/Swiss-Prot

A0A1L8GE03, P13904, Q3KQ98

UniProtKB/TrEMBL

Q8AVZ0

Related

ENSXLAP00005013132.1, ENSXLAT00005013312.1

Conserved Domains (3) summary

smart00520
Location:11 → 100

BASIC; Basic domain in HLH proteins of MYOD family

cd18936
Location:91 → 151

bHLH_TS_MYOD1_Myf3; basic helix-loop-helix (bHLH) domain found in myoblast determination protein 1 (MYOD1) and similar proteins

pfam12232
Location:162 → 230

Myf5; Myogenic determination factor 5

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054378.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

23265125..23267706 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)