U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

rgs12b regulator of G protein signaling 12b [ Danio rerio (zebrafish) ]

Gene ID: 378970, updated on 10-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
rgs12bprovided by ZNC
Official Full Name
regulator of G protein signaling 12bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-031006-13
See related
Ensembl:ENSDARG00000036774 AllianceGenome:ZFIN:ZDB-GENE-031006-13
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb958; rgs12; RGS12TS; RGS12TS-I; RGS12TS-L; RGS12TS-S
Summary
Predicted to enable GTPase activator activity. Predicted to act upstream of or within signal transduction. Predicted to be located in cytoplasm and dendrite. Is expressed in retina and ventricular zone. Orthologous to human RGS12 (regulator of G protein signaling 12). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 1
Exon count:
22
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (41201231..41290638, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (40498763..40587829, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor-related protein associated protein 1 Neighboring gene docking protein 7b Neighboring gene huntingtin Neighboring gene si:ch211-89o9.4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
regulator of G-protein signaling 12; regulator of G-protein signaling 12b
Names
regulator of G-protein signalling 12

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214724.1 → NP_999889.1  regulator of G-protein signaling 12b

    See identical proteins and their annotated locations for NP_999889.1

    Status: PROVISIONAL

    Source sequence(s)
    AY427669
    UniProtKB/TrEMBL
    Q6T9C3, Q6T9C4
    Related
    ENSDARP00000015580.7, ENSDART00000022546.9
    Conserved Domains (9) summary
    cd01817
    Location:993 → 1065
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    cd08742
    Location:741 → 855
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:239 → 372
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    pfam02188
    Location:1195 → 1216
    GoLoco; GoLoco motif
    pfam16611
    Location:1141 → 1180
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:1307 → 1367
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:861 → 954
    RGS12_us1; Unstructured region of RGS12
    cl00155
    Location:1065 → 1132
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    41201231..41290638 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005160017.4 → XP_005160074.1  regulator of G-protein signaling 12 isoform X5

    See identical proteins and their annotated locations for XP_005160074.1

    UniProtKB/TrEMBL
    Q6T9C3, Q6T9C4
    Conserved Domains (9) summary
    cd01817
    Location:993 → 1065
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    cd08742
    Location:741 → 855
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:239 → 372
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    pfam02188
    Location:1195 → 1216
    GoLoco; GoLoco motif
    pfam16611
    Location:1141 → 1180
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:1307 → 1367
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:861 → 954
    RGS12_us1; Unstructured region of RGS12
    cl00155
    Location:1065 → 1132
    UBQ; Ubiquitin-like proteins

  2. XM_009292984.2 → XP_009291259.1  regulator of G-protein signaling 12 isoform X2

    See identical proteins and their annotated locations for XP_009291259.1

    UniProtKB/TrEMBL
    Q6T9C1, Q6T9C5
    Conserved Domains (6) summary
    cd01817
    Location:993 → 1065
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    cd08742
    Location:741 → 855
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:239 → 372
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    pfam16613
    Location:861 → 954
    RGS12_us1; Unstructured region of RGS12
    cl00155
    Location:1065 → 1132
    UBQ; Ubiquitin-like proteins

  3. XM_009292979.2 → XP_009291254.1  regulator of G-protein signaling 12 isoform X1

    See identical proteins and their annotated locations for XP_009291254.1

    UniProtKB/TrEMBL
    Q6SPF1, Q6T9C2
    Conserved Domains (9) summary
    cd01817
    Location:993 → 1065
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    cd08742
    Location:741 → 855
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:239 → 372
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    pfam02188
    Location:1195 → 1216
    GoLoco; GoLoco motif
    pfam16611
    Location:1141 → 1193
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:1307 → 1385
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:861 → 970
    RGS12_us1; Unstructured region of RGS12
    cl25424
    Location:1065 → 1132
    TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...

  4. XM_021481388.1 → XP_021337063.1  regulator of G-protein signaling 12 isoform X1

    UniProtKB/TrEMBL
    Q6SPF1, Q6T9C2
    Conserved Domains (9) summary
    cd01817
    Location:993 → 1065
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    cd08742
    Location:741 → 855
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:239 → 372
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    pfam02188
    Location:1195 → 1216
    GoLoco; GoLoco motif
    pfam16611
    Location:1141 → 1193
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:1307 → 1385
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:861 → 970
    RGS12_us1; Unstructured region of RGS12
    cl25424
    Location:1065 → 1132
    TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...

  5. XM_009292995.3 → XP_009291270.1  regulator of G-protein signaling 12 isoform X3

    UniProtKB/TrEMBL
    A0A8M3AU63
    Conserved Domains (7) summary
    cd01817
    Location:333 → 405
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    cd08742
    Location:81 → 195
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:535 → 556
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam16611
    Location:481 → 520
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:647 → 707
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:201 → 294
    RGS12_us1; Unstructured region of RGS12
    cl00155
    Location:405 → 472
    UBQ; Ubiquitin-like proteins

  6. XM_009293006.3 → XP_009291281.1  regulator of G-protein signaling 12 isoform X4

    UniProtKB/TrEMBL
    A0A8M3B2C1
    Conserved Domains (7) summary
    cd01817
    Location:319 → 391
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    cd08742
    Location:67 → 181
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:521 → 542
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam16611
    Location:467 → 506
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:633 → 693
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:187 → 280
    RGS12_us1; Unstructured region of RGS12
    cl00155
    Location:391 → 458
    UBQ; Ubiquitin-like proteins

RNA

  1. XR_002459982.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous