emx1 empty spiracles homeobox 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: emx1provided by ZNC
Official Full Name: empty spiracles homeobox 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-031007-7
See related: Ensembl:ENSDARG00000039569 AllianceGenome:ZFIN:ZDB-GENE-031007-7
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:101821
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within pronephric distal tubule development. Predicted to be active in nucleus. Is expressed in several structures, including forebrain; forebrain neural keel; neural plate; presumptive telencephalon; and pronephros. Orthologous to human EMX1 (empty spiracles homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (15004398..15010666)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (14873406..14879674)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Emx1 is a key component of the pronephros segmentation network, which has implications for understanding the genetic regulatory cascades that orchestrate vertebrate nephron patterning.
Title: Homeogene emx1 is required for nephron distal segment development in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pronephric distal tubule development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pronephric distal tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein EMX1

Names: empty spiracles homolog 1; empty spiracles-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198144.2 → NP_937787.1 homeobox protein EMX1

See identical proteins and their annotated locations for NP_937787.1

Status: PROVISIONAL

Source sequence(s)

BC134029

UniProtKB/Swiss-Prot

Q804S6

UniProtKB/TrEMBL

A3KNV6

Related

ENSDARP00000057809.5, ENSDART00000057810.6

Conserved Domains (2) summary

COG5576
Location:82 → 192

COG5576; Homeodomain-containing transcription factor [Transcription]

pfam00046
Location:137 → 189

Homeobox; Homeobox domain