GHSR growth hormone secretagogue receptor [Gallus gallus (chicken)] - Gene

Summary

Symbol: GHSRprovided by CGNC
Full Name: growth hormone secretagogue receptorprovided by CGNC
Primary source: CGNC:6983
See related: Ensembl:ENSGALG00010018549
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	9	NC_052540.1 (19000566..19013919)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	9	NC_052581.1 (18788656..18801402)

Chromosome 9 - NC_052540.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This is the first study to demonstrate that single nucleotide polymorphisms in GHSR can increase appetite, growth traits, expression and level of GHRL, suggesting a hunger signal role for endogenous GHRL.
Title: Is really endogenous ghrelin a hunger signal in chickens? Association of GHSR SNPs with increase appetite, growth traits, expression and serum level of GHRL, and GH.
Expression levels of ghrelin, GOAT and GHS-R1a in the brain were independently regulated from that in the proventriculus in male chickens.
Title: Correlation of ghrelin concentration and ghrelin, ghrelin-O-acetyltransferase (GOAT) and growth hormone secretagogue receptor 1a mRNAs expression in the proventriculus and brain of the growing chicken.
For GHSR, rs16675844 had significant effects on FI and FCR (P < 0.01), and that rs14678932 showed significant association with BWG and FI (P < 0.05). Rs14011780 of IGF1R was strongly associated with BW49, BW70, and FCR (P < 0.05)
Title: Associations of polymorphisms in GHRL, GHSR, and IGF1R genes with feed efficiency in chickens.
SNPs of GHSR C3286 > T and TGFB2 T(-640) > C were genotyped in sire and dam lines of a broiler chicken to evaluate the association with the growth and body composition traits.
Title: Association of single nucleotide polymorphism of GHSR and TGFB2 genes with growth and body composition traits in sire and dam lines of a broiler chicken.
SNPs were identified in chicken GHRL (cGHRL), chicken GHSR (cGHSR), dGHRL, and dGHSR genes. Both cGHRL and dGHRL were expressed predominantly in the proventriculus, whereas highest cGHSR and dGHSR were detected in the breast muscle and pituitary.
Title: Molecular characterization of the ghrelin and ghrelin receptor genes and effects on fat deposition in chicken and duck.
Five polymorphisms (four SNP and a 'GGTACA' indel) of GHSR gene were genotyped in a F(2) full sib chicken population to investigate their associations with production traits.
Title: Associations of GHSR gene polymorphisms with chicken growth and carcass traits.
Chicken GHS-R gene is composed of two exons separated by an intron. Two GHS-R mRNA species, cGHS-R1a and cGHS-R1a-variant (cGHS-R1aV) are generated by alternative splicing of a primary transcript.
Title: Molecular characterization of chicken growth hormone secretagogue receptor gene.
The partial cloning of two chicken GHS-R (cGHS-R) isoforms, cGHS-R1a and cGHS-R1c, is described.
Title: Distribution and regulation of chicken growth hormone secretagogue receptor isoforms.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables growth hormone secretagogue receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in hormone-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: growth hormone secretagogue receptor type 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204394.2 → NP_989725.1 growth hormone secretagogue receptor type 1

See identical proteins and their annotated locations for NP_989725.1

Status: VALIDATED

Source sequence(s)

JAENSK010000240

UniProtKB/TrEMBL

Q7ZT14, Q7ZZJ9

Related

ENSGALP00010026793.1, ENSGALT00010044874.1

Conserved Domains (2) summary

pfam00001
Location:41 → 304

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:36 → 322

7tm_4; Olfactory receptor