ZP3 zona pellucida sperm-binding protein 3 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: ZP3provided by CGNC
Official Full Name: zona pellucida sperm-binding protein 3provided by CGNC
Primary source: CGNC:49138
See related: Ensembl:ENSGALG00010021314
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: ZPC; Zp-3
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Genomic context

Location:: chromosome: 10

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	10	NC_052541.1 (2659896..2662294)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	10	NC_052582.1 (2532596..2535003)

Chromosome 10 - NC_052541.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

chicken ZP3 was separated into four major and distinct isoforms with different pI in 2D-PAGE.
Title: Diverse lectin-binding specificity of four ZP3 glycoprotein isoforms with a discrete isoelectric point in chicken egg coat.
Crystal structure of an avian homolog of ZP3 at 2.0 A resolution. The structure unveils the fold of a complete ZP domain module in a homodimeric arrangement required for secretion and reveals how EHP prevents premature incorporation of ZP3 into the ZP.
Title: Insights into egg coat assembly and egg-sperm interaction from the X-ray structure of full-length ZP3.
Chick ZP3 is secreted to the apical aspect of chicken granulosa cells towards the perivitelline matrix.
Title: The chicken homologue of zona pellucida protein-3 is synthesized by granulosa cells.
ZP1, in addition to ZPC, plays a major role in the initial interactions between sperm and egg.
Title: Interaction of sperm with purified native chicken ZP1 and ZPC proteins.
Involvement in the formation of quail zona pellucida
Title: Involvement of interaction of ZP1 and ZPC in the formation of quail perivitelline membrane.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables acrosin binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in binding of sperm to zona pellucida	IEA Inferred from Electronic Annotation more info	PubMed
involved_in egg coat formation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of acrosome reaction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: zona pellucida sperm-binding protein 3

Names: sperm receptor; zona pellucida C protein; zona pellucida glycoprotein 3 (sperm receptor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.