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slbo slow border cells [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37889, updated on 2-Nov-2024

Summary

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Official Symbol
slboprovided by FlyBase
Official Full Name
slow border cellsprovided by FlyBase
Primary source
FLYBASE:FBgn0005638
Locus tag
Dmel_CG4354
See related
AllianceGenome:FB:FBgn0005638
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
C/EBP; CG4354; DC/EBP; Dm-c/EBP; DM8; DmC/EBP; Dmel\CG4354; fs(2)7; fs(2)8; fs(2)ry7; fs(2)ry8; Slbo; SLBO; slobo
Summary
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in border follicle cell migration; positive regulation of border follicle cell migration; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including embryonic head epidermis; epidermis; follicle cell; gut section; and nephrocyte. Human ortholog(s) of this gene implicated in acute myeloid leukemia and primary immunodeficiency disease. Orthologous to several human genes including CEBPA (CCAAT enhancer binding protein alpha). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See slbo in Genome Data Viewer
Location:
60C6-60C6; 2-106 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24331522..24334307, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20219045..20221830, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene beta-Tubulin at 60D Neighboring gene long non-coding RNA:CR44810 Neighboring gene long non-coding RNA:CR44282 Neighboring gene blistered Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila C/EBP: a tissue-specific DNA-binding protein required for embryonic development. Rørth P, et al. Genes Dev, 1992 Dec. PMID 1459454
  2. Migration on the borderline. Greaves S. Nat Cell Biol, 2001 Feb. PMID 11175759
  3. An enhancer region within the copia untranslated leader contains binding sites for Drosophila regulatory proteins. Wilson S, et al. Gene, 1998 Mar 16. PMID 9524274
  4. The pruned gene encodes the Drosophila serum response factor and regulates cytoplasmic outgrowth during terminal branching of the tracheal system. Guillemin K, et al. Development, 1996 May. PMID 8625824
  5. GAGA Regulates Border Cell Migration in Drosophila. Ogienko AA, et al. Int J Mol Sci, 2020 Oct 10. PMID 33050455, Free PMC Article

See all (180) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data conclude that the regulatory feedback loop between Tj and Slbo is necessary for achieving the correct activity levels of migration-regulating factors to ensure proper BCC motility.
    Title: The Maf factor Traffic jam both enables and inhibits collective cell migration in Drosophila oogenesis.
  2. downregulated in delaminating epithelia as expression of Slbo is upregulated; this expression pattern during cell migration is achieved by negative feedback - slbo represses Trbl expression and trbl is necessary and sufficient to promote Slbo protein turnover
    Title: The kinase domain of Drosophila Tribbles is required for turnover of fly C/EBP during cell migration.
  3. Opposing interactions between Drosophila cut and the C/EBP encoded by slow border cells direct apical constriction and epithelial invagination
    Title: Opposing interactions between Drosophila cut and the C/EBP encoded by slow border cells direct apical constriction and epithelial invagination.
  4. In anterior follicle cells exposed to a Dpp morphogen gradient, high and low levels of slbo and bun, respectively, are established by modulation of Notch signaling to direct threshold cell fates.
    Title: Notch signaling links interactions between the C/EBP homolog slow border cells and the GILZ homolog bunched during cell migration.
  5. The slbo protein, a C/EBP family transcriptional activator, is required for Border cells to become migratory.
    Title: Systematic analysis of the transcriptional switch inducing migration of border cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
slow border cells
Names
CCAAT/enhancer binding protein
CG4354-PA
CG4354-PB
slbo-PA
slbo-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24331522..24334307 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079119.3 → NP_523843.1  slow border cells, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523843.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q02637, Q9W183
    UniProtKB/TrEMBL
    A0A0B4LGG2
    Related
    FBpp0072179
    Conserved Domains (1) summary
    cd14693
    Location:362 → 420
    bZIP_CEBP; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein (CEBP) and similar proteins: a DNA-binding and dimerization domain

  2. NM_001299907.1 → NP_001286836.1  slow border cells, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286836.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q02637, Q9W183
    UniProtKB/TrEMBL
    A0A0B4LGG2
    Conserved Domains (1) summary
    cd14693
    Location:362 → 420
    bZIP_CEBP; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein (CEBP) and similar proteins: a DNA-binding and dimerization domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LGG2 A0A0B4LGG2
Q02637.3 Q02637

Gene LinkOut

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