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GH growth hormone [ Gallus gallus (chicken) ]

Gene ID: 378781, updated on 17-Aug-2024

Summary

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Official Symbol
GHprovided by CGNC
Official Full Name
growth hormoneprovided by CGNC
Primary source
CGNC:49117
See related
Ensembl:ENSGALG00010023602
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
GH1; cGH
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Genomic context

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Location:
chromosome: 27
Exon count:
5
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 27 NC_052558.1 (1267814..1271320, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 27 NC_052599.1 (2486499..2490005, complement)

Chromosome 27 - NC_052558.1Genomic Context describing neighboring genes Neighboring gene leucine-rich repeat-containing protein 37A-like Neighboring gene uncharacterized LOC121107702 Neighboring gene uncharacterized LOC107055278 Neighboring gene RAD52 motif containing 1 Neighboring gene CD79b molecule Neighboring gene sodium voltage-gated channel alpha subunit 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel Alui-polymorphism in the fourth intron of the chicken growth hormone gene. Kulibaba RA, et al. Tsitol Genet, 2017 Jan-Feb. PMID 30484611
  2. Structure of the chicken growth hormone-encoding gene and its promoter region. Tanaka M, et al. Gene, 1992 Mar 15. PMID 1555772
  3. Chicken growth hormone cDNA sequence. Lamb IC, et al. Nucleic Acids Res, 1988 Oct 11. PMID 3174454, Free PMC Article
  4. [Genetic engineering of peptide hormones. I. Cloning and primary structure of cDNA of chicken growth hormone]. Zhvirblis GS, et al. Mol Biol (Mosk), 1987 Nov-Dec. PMID 3482121
  5. Identification of a novel GH isoform: a possible link between GH and melanocortin systems in the developing chicken eye. Takeuchi S, et al. Endocrinology, 2001 Dec. PMID 11713210

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Growth Hormone (GH) Crosses the Blood-Brain Barrier (BBB) and Induces Neuroprotective Effects in the Embryonic Chicken Cerebellum after a Hypoxic Injury.
    Title: Growth Hormone (GH) Crosses the Blood-Brain Barrier (BBB) and Induces Neuroprotective Effects in the Embryonic Chicken Cerebellum after a Hypoxic Injury.
  2. A novel AluI polymorphism in the fourth intron of the chicken growth hormone gene has been reported.
    Title: A novel Alui-polymorphism in the fourth intron of the chicken growth hormone gene.
  3. This is the first study to demonstrate that single nucleotide polymorphisms in GHSR can increase appetite, growth traits, expression and level of GHRL, suggesting a hunger signal role for endogenous GHRL.
    Title: Is really endogenous ghrelin a hunger signal in chickens? Association of GHSR SNPs with increase appetite, growth traits, expression and serum level of GHRL, and GH.
  4. There is a negative glucocorticoid response-like element located in the +591/+609 region within the first intron of chicken growth hormone (cGH), which is essential for the down-regulation of cGH expression.
    Title: Negative Glucocorticoid Response-Like Element from the First Intron of the Chicken Growth Hormone Gene Represses Gene Expression in the Rat Pituitary Tumor Cell Line.
  5. It is shown that in all examined chicken populations the growth hormone gene is polymorphic.
    Title: [MspI-POLYMORPHISM IN FOURTH INTRON OF THE GROWTH HORMONE GENE IN CHICKEN POPULATIONS OF DIFFERENT BREEDS. ANALYSIS OF THE CAUSES OF ADDITIONAL RESTRICTION PATTERN ORIGIN].
  6. The molecular mechanisms underlying glucocorticoid recruitment of somatotrophs during embryogenesis were studied; these provide insight into glucocorticoid-induced developmental changes in other tissues and cell types.
    Title: Mechanisms involved in glucocorticoid induction of pituitary GH expression during embryonic development.
  7. T185G growth hormone polymorphism was significantly associated with the egg production traits in chickens.
    Title: Association of chicken growth hormone polymorphisms with egg production.
  8. GHRH stimulates testicular GH secretion in an autocrine or paracrine manner.
    Title: Growth hormone (GH) and GH-releasing hormone (GHRH): Co-localization and action in the chicken testis.
  9. The results indicate that high frequency of I, C and A alleles corresponds to the egg-laying chicken lines.
    Title: [Polymorphism of prolactin and growth hormone genes in chicken lines of Ukrainian selection].
  10. analysis of differential abilities of chicken Pit1 isoforms to regulate the GH promoter
    Title: Differential abilities of chicken Pit1 isoforms to regulate the GH promoter: evidence for synergistic activation.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables growth hormone receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in animal organ development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in growth hormone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of growth IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to nutrient levels IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
somatotropin
Names
growth hormone 1
neural retina growth hormone

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204359.2 → NP_989690.1  somatotropin precursor

    See identical proteins and their annotated locations for NP_989690.1

    Status: PROVISIONAL

    Source sequence(s)
    X17618
    UniProtKB/Swiss-Prot
    P08998, Q53Z10
    UniProtKB/TrEMBL
    H6UQ58, H6UQ60
    Related
    ENSGALP00010034935.1, ENSGALT00010057492.1
    Conserved Domains (1) summary
    cd10285
    Location:35 → 214
    somatotropin_like; Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052558.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    1267814..1271320 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052599.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    2486499..2490005 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08998.2 GenPept UniProtKB/Swiss-Prot:P08998

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.