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BMP2 bone morphogenetic protein 2 [ Gallus gallus (chicken) ]

Gene ID: 378779, updated on 17-Aug-2024

Summary

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Official Symbol
BMP2provided by CGNC
Official Full Name
bone morphogenetic protein 2provided by CGNC
Primary source
CGNC:49116
See related
Ensembl:ENSGALG00010018503
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See BMP2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
17
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (14796478..15040250, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (14710817..14948169, complement)

Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene microRNA 1756b Neighboring gene uncharacterized LOC107052867 Neighboring gene uncharacterized LOC107052869 Neighboring gene uncharacterized LOC121110386 Neighboring gene uncharacterized LOC124417872 Neighboring gene fermitin family member 1 Neighboring gene uncharacterized LOC112532092 Neighboring gene uncharacterized LOC121110391 Neighboring gene leucine rich repeat neuronal 4 Neighboring gene family with sequence similarity 161 member A Neighboring gene chaperonin containing TCP1 subunit 4 Neighboring gene Sec23 homolog B, coat complex II component Neighboring gene D-tyrosyl-tRNA deacylase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. BMP signaling controls buckling forces to modulate looping morphogenesis of the gut. Nerurkar NL, et al. Proc Natl Acad Sci U S A, 2017 Feb 28. PMID 28193855, Free PMC Article
  2. Role of bone morphogenic protein 2 in retinal patterning and retinotectal projection. Sakuta H, et al. J Neurosci, 2006 Oct 18. PMID 17050724, Free PMC Article
  3. CBF1 controls the retinotectal topographical map along the anteroposterior axis through multiple mechanisms. Takahashi H, et al. Development, 2003 Nov. PMID 12954716
  4. Bone morphogenetic protein 2 inhibits FSH responsiveness in hen granulosa cells. Haugen MJ, et al. Reproduction, 2010 Oct. PMID 20639315
  5. Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb. Francis PH, et al. Development, 1994 Jan. PMID 8119128

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bmp2 expressed in the dorsal mesentery establishes differential elongation rates between the gut tube and mesentery, thereby regulating the compressive forces that buckle the gut tube into loops.
    Title: BMP signaling controls buckling forces to modulate looping morphogenesis of the gut.
  2. The finding that retinal gene expression for BMP2, 4, 7 and their receptors are not affected by short-term optical defocus contrasts with previous observations of sign-dependent expression changes for the same genes in the RPE.
    Title: Differential gene expression of BMP2 and BMP receptors in chick retina & choroid induced by imposed optical defocus.
  3. Results indicate that BMP-2 is not a component of the hLAMP-1-positive particulate matrix in the chick.
    Title: The hLAMP-1-positive particulate matrix involved in cardiac mesenchyme formation in the chick does not include BMP-2.
  4. SMAD1 has a role in migration of cardiac progenitor cells by integrating BMP2 and Wnt3a signals
    Title: Smad1 transcription factor integrates BMP2 and Wnt3a signals in migrating cardiac progenitor cells.
  5. These data suggest that developmental cardiotoxicity induced by perfluorooctanoic acid likely involves both PPARalpha and BMP2 pathways.
    Title: Perfluorooctanoic acid induced-developmental cardiotoxicity: are peroxisome proliferator activated receptor α (PPARα) and bone morphorgenic protein 2 (BMP2) pathways involved?
  6. locus affecting comb mass (a sexual ornament in the chicken and fecundity) was identified.This locus contains two tightly-linked genes, BMP2 and HAO1, which together produce the range of pleiotropic effects seen.
    Title: A sexual ornament in chickens is affected by pleiotropic alleles at HAO1 and BMP2, selected during domestication.
  7. Transforming growth factor-beta3 (TGFbeta3), bone morphogenetic protein 2 (BMP2), and vascular endothelial growth factor A (VEGFA) are expressed in spatiotemporally distinct patterns and at significantly different levels within remodeling embryonic valves.
    Title: Transforming growth factor β, bone morphogenetic protein, and vascular endothelial growth factor mediate phenotype maturation and tissue remodeling by embryonic valve progenitor cells: relevance for heart valve tissue engineering.
  8. Our data suggest that miR-140 has a large number of targets conserved between human and chicken and we validate one of these, BMP2.
    Title: mRNA expression profiling reveals conserved and non-conserved miR-140 targets.
  9. BMP2 and its associated signaling mechanisms modulate FSHR mRNA expression and FSH reponsiveness in granulosa cells from prehierarchal follicles.
    Title: Bone morphogenetic protein 2 inhibits FSH responsiveness in hen granulosa cells.
  10. FGF8 increased smooth muscle differentiation.
    Title: Arterial pole progenitors interpret opposing FGF/BMP signals to proliferate or differentiate.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables BMP receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
bone morphogenetic protein 2
Names
BMP-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398170.1 → NP_001385099.1  bone morphogenetic protein 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL585496, AL587038, AY237249, BU137064, BU347378, BU444424, BX277403, JAENSK010000062
    Related
    ENSGALP00010026685.1, ENSGALT00010044763.1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    14796478..15040250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046938393.1 → XP_046794349.1  bone morphogenetic protein 2 isoform X1

  2. XM_046938397.1 → XP_046794353.1  bone morphogenetic protein 2 isoform X1

  3. XM_046938394.1 → XP_046794350.1  bone morphogenetic protein 2 isoform X1

  4. XM_046938395.1 → XP_046794351.1  bone morphogenetic protein 2 isoform X1

  5. XM_046938396.1 → XP_046794352.1  bone morphogenetic protein 2 isoform X1

  6. XM_046938392.1 → XP_046794348.1  bone morphogenetic protein 2 isoform X1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    14710817..14948169 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046912906.1 → XP_046768862.1  bone morphogenetic protein 2 isoform X1

  2. XM_046912908.1 → XP_046768864.1  bone morphogenetic protein 2 isoform X1

  3. XM_046912910.1 → XP_046768866.1  bone morphogenetic protein 2 isoform X1

  4. XM_046912913.1 → XP_046768869.1  bone morphogenetic protein 2 isoform X1

  5. XM_046912914.1 → XP_046768870.1  bone morphogenetic protein 2 isoform X1

  6. XM_046912912.1 → XP_046768868.1  bone morphogenetic protein 2 isoform X1

  7. XM_046912909.1 → XP_046768865.1  bone morphogenetic protein 2 isoform X1

  8. XM_046912911.1 → XP_046768867.1  bone morphogenetic protein 2 isoform X1

  9. XM_046912918.1 → XP_046768874.1  bone morphogenetic protein 2 isoform X1

  10. XM_046912915.1 → XP_046768871.1  bone morphogenetic protein 2 isoform X1

  11. XM_046912916.1 → XP_046768872.1  bone morphogenetic protein 2 isoform X1

  12. XM_046912917.1 → XP_046768873.1  bone morphogenetic protein 2 isoform X1

  13. XM_046912907.1 → XP_046768863.1  bone morphogenetic protein 2 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_204358.1: Suppressed sequence

    Description
    NM_204358.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q90751.1 GenPept UniProtKB/Swiss-Prot:Q90751

Gene LinkOut

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Molecular Biology Databases
Research Materials