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drd2l dopamine receptor D2 like [ Danio rerio (zebrafish) ]

Gene ID: 378718, updated on 18-Sep-2024

Summary

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Official Symbol
drd2lprovided by ZNC
Official Full Name
dopamine receptor D2 likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030910-1
See related
Ensembl:ENSDARG00000014858 AllianceGenome:ZFIN:ZDB-GENE-030910-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
drd2b
Summary
Predicted to enable G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; negative regulation of adenylate cyclase activity; and regulation of ion transport. Predicted to act upstream of or within dopamine receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be active in glutamatergic synapse. Predicted to be integral component of presynaptic membrane. Is expressed in brain and spinal cord. Human ortholog(s) of this gene implicated in several diseases, including end stage renal disease; mental depression; migraine with aura; obesity; and type 2 diabetes mellitus. Orthologous to human DRD2 (dopamine receptor D2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See drd2l in Genome Data Viewer
Location:
chromosome: 16
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (54248601..54291826)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (54390367..54433824)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene kin of IRRE-like protein 2 Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 1 Neighboring gene tryptase gamma-like Neighboring gene ETHE1 persulfide dioxygenase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolution and expression of D2 and D3 dopamine receptor genes in zebrafish. Boehmler W, et al. Dev Dyn, 2004 Jul. PMID 15188433
  2. Prolactin receptor signaling mediates the osmotic response of embryonic zebrafish lactotrophs. Liu NA, et al. Mol Endocrinol, 2006 Apr. PMID 16339273
  3. Sleep deprivation caused a memory defects and emotional changes in a rotenone-based zebrafish model of Parkinson's disease. Lv DJ, et al. Behav Brain Res, 2019 Oct 17. PMID 31195038
  4. Dopamine inhibits reproduction in female zebrafish (Danio rerio) via three pituitary D2 receptor subtypes. Fontaine R, et al. Endocrinology, 2013 Feb. PMID 23295741
  5. Behavioral Analysis of Dopaminergic Activation in Zebrafish and Rats Reveals Similar Phenotypes. Ek F, et al. ACS Chem Neurosci, 2016 May 18. PMID 26947759

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha2-adrenergic receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables dopamine neurotransmitter receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled dopamine receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-inhibiting adrenergic receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within adenylate cyclase-inhibiting dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating dopamine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of dopamine secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of potassium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dopamine receptor D2 like
Names
dopamine receptor D2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_197935.1 → NP_922917.1  dopamine receptor D2 like

    See identical proteins and their annotated locations for NP_922917.1

    Status: PROVISIONAL

    Source sequence(s)
    AY333791
    UniProtKB/TrEMBL
    Q7T1A2
    Related
    ENSDARP00000023147.6, ENSDART00000002856.7
    Conserved Domains (2) summary
    pfam00001
    Location:57 → 420
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:55 → 186
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    54248601..54291826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068213911.1 → XP_068070012.1  dopamine receptor D2 like isoform X1

    Related
    ENSDARP00000127653.1, ENSDART00000156915.3
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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