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igf1.L insulin like growth factor 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 378699, updated on 4-Nov-2024

Summary

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Official Symbol
igf1.L
Official Full Name
insulin like growth factor 1 L homeolog
Primary source
Xenbase:XB-GENE-6252361
See related
AllianceGenome:Xenbase:XB-GENE-6252361
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
igf1; IGF-I; igf-1; xigf1; igf1-A; igf1.S
Summary
Predicted to enable growth factor activity; hormone activity; and insulin-like growth factor receptor binding activity. Predicted to act upstream of or within several processes, including insulin-like growth factor receptor signaling pathway; negative regulation of apoptotic process; and regulation of protein phosphorylation. Predicted to be located in extracellular space. Is expressed in mesenchyme and mesoderm. Human ortholog(s) of this gene implicated in several diseases, including acne; brain ischemia; diabetes mellitus (multiple); myopia; and neurodegenerative disease (multiple). Orthologous to human IGF1 (insulin like growth factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
not in current annotation release
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Genomic context

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Location:
chromosome: 3L

Bibliography

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Related articles in PubMed

  1. Insulin-like growth factor 1 regulation of proliferation and differentiation of Xenopus laevis myogenic cells in vitro. Miyata S, et al. In Vitro Cell Dev Biol Anim, 2017 Mar. PMID 27699652
  2. Evidence that Xenopus laevis contains two different nonallelic insulin-like growth factor-I genes. Shuldiner AR, et al. Biochem Biophys Res Commun, 1990 Jan 15. PMID 2302204
  3. Evolution of insulin-like growth factor I (IGF-I): structure and expression of an IGF-I precursor from Xenopus laevis. Kajimoto Y, et al. Mol Endocrinol, 1990 Feb. PMID 2330002
  4. The IGF pathway regulates head formation by inhibiting Wnt signaling in Xenopus. Richard-Parpaillon L, et al. Dev Biol, 2002 Apr 15. PMID 11944947
  5. Neural and head induction by insulin-like growth factor signals. Pera EM, et al. Dev Cell, 2001 Nov. PMID 11709186

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Thus, IGF-1 affects only adult-type myogenic cells in the presence of T3 and helps accelerate dorsal muscle remodeling during metamorphosis.
    Title: Insulin-like growth factor 1 regulation of proliferation and differentiation of Xenopus laevis myogenic cells in vitro.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables hormone activity IEA
Inferred from Electronic Annotation
more info
  
enables insulin-like growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
insulin-like growth factor I-A
Names
IGF-I'
IGF-IA
insulin like growth factor 1 S homeolog
insulin-like growth factor 1 (somatomedin C)
somatomedin
somatomedin-C
xIGF-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163393.1 → NP_001156865.1  insulin-like growth factor I-A precursor

    See identical proteins and their annotated locations for NP_001156865.1

    Status: PROVISIONAL

    Source sequence(s)
    M29857
    UniProtKB/Swiss-Prot
    P16501
    Conserved Domains (1) summary
    cd04368
    Location:49 → 116
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16501.2 GenPept UniProtKB/Swiss-Prot:P16501

Gene LinkOut

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Molecular Biology Databases
Research Materials