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twist1.S twist family bHLH transcription factor 1 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 378698, updated on 17-Aug-2024

Summary

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Official Symbol
twist1.S
Official Full Name
twist family bHLH transcription factor 1 S homeolog
Primary source
Xenbase:XB-GENE-865309
Locus tag
XELAEV_18033027mg
See related
EnsemblRapid:ENSXLAG00005026280
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
Xtwi; X-twi; twist; Xtwist; twist1; twist1-a; twist1-b
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Genomic context

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Location:
chromosome: 6S
Exon count:
2
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 6S NC_054382.1 (31069927..31073072, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 6S NC_030735.1 (30542306..30545451, complement)

Chromosome 6S - NC_054382.1Genomic Context describing neighboring genes Neighboring gene sorting nexin 13 S homeolog Neighboring gene histone deacetylase 9 S homeolog Neighboring gene Fer3-like bHLH transcription factor S homeolog Neighboring gene DNA-directed RNA polymerase I subunit RPA43-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Xenopus mRNA related to Drosophila twist is expressed in response to induction in the mesoderm and the neural crest. Hopwood ND, et al. Cell, 1989 Dec 1. PMID 2590945
  2. Function of chromatin modifier Hmgn1 during neural crest and craniofacial development. Ihewulezi C, et al. Genesis, 2021 Oct. PMID 34478234, Free PMC Article
  3. Interactions between Twist and other core epithelial-mesenchymal transition factors are controlled by GSK3-mediated phosphorylation. Lander R, et al. Nat Commun, 2013. PMID 23443570, Free PMC Article
  4. Oxidative stress drives disulfide bond formation between basic helix-loop-helix transcription factors. Danciu TE, et al. J Cell Biochem, 2010 Feb 1. PMID 19950203
  5. Cardiac neural crest ablation alters Id2 gene expression in the developing heart. Martinsen BJ, et al. Dev Biol, 2004 Aug 1. PMID 15242799

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Function of chromatin modifier Hmgn1 during neural crest and craniofacial development.
    Title: Function of chromatin modifier Hmgn1 during neural crest and craniofacial development.
  2. Interaction with Snail1/2, and Twist function more generally, is regulated by GSK-3-beta-mediated phosphorylation of conserved sites in the WR domain.
    Title: Interactions between Twist and other core epithelial-mesenchymal transition factors are controlled by GSK3-mediated phosphorylation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC154486

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neural crest formation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
twist-related protein
Names
T18
X-twist
twist basic helix-loop-helix transcription factor 1
twist homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085883.1 → NP_001079352.1  twist-related protein

    See identical proteins and their annotated locations for NP_001079352.1

    Status: PROVISIONAL

    Source sequence(s)
    BC123238
    UniProtKB/Swiss-Prot
    P13903, Q0IHA6
    UniProtKB/TrEMBL
    A0A974CIM1
    Related
    ENSXLAP00005078071.1, ENSXLAT00005079662.1
    Conserved Domains (1) summary
    pfam00010
    Location:73 → 123
    HLH; Helix-loop-helix DNA-binding domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054382.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    31069927..31073072 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13903.1 GenPept UniProtKB/Swiss-Prot:P13903

Gene LinkOut

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Molecular Biology Databases
Research Materials