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Morn2 MORN repeat containing 2 [ Mus musculus (house mouse) ]

Gene ID: 378462, updated on 10-Mar-2024

Summary

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Official Symbol
Morn2provided by MGI
Official Full Name
MORN repeat containing 2provided by MGI
Primary source
MGI:MGI:2674071
See related
Ensembl:ENSMUSG00000045257 AllianceGenome:MGI:2674071
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mopt
Summary
Predicted to act upstream of or within cell differentiation and spermatogenesis. Predicted to be located in cytoplasmic vesicle and nucleus. Orthologous to human MORN2 (MORN repeat containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 89.9), kidney adult (RPKM 7.0) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Morn2 in Genome Data Viewer
Location:
17 E3; 17 50.63 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (80597626..80613130)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (80290203..80300096)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7559 Neighboring gene STARR-positive B cell enhancer ABC_E5631 Neighboring gene gem nuclear organelle associated protein 6 Neighboring gene STARR-positive B cell enhancer ABC_E3217 Neighboring gene STARR-positive B cell enhancer ABC_E5632 Neighboring gene tetratricopeptide repeat domain 39D Neighboring gene STARR-seq mESC enhancer starr_43307 Neighboring gene STARR-seq mESC enhancer starr_43308 Neighboring gene DExH-box helicase 57 Neighboring gene STARR-positive B cell enhancer ABC_E7560 Neighboring gene Rho guanine nucleotide exchange factor 33 Neighboring gene STARR-seq mESC enhancer starr_43309 Neighboring gene STARR-seq mESC enhancer starr_43310 Neighboring gene predicted gene 10190 Neighboring gene STARR-seq mESC enhancer starr_43312 Neighboring gene SOS Ras/Rac guanine nucleotide exchange factor 1 Neighboring gene STARR-seq mESC enhancer starr_43313 Neighboring gene ribosomal protein L17 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and characterization of a novel mouse and human MOPT gene containing MORN-motif protein in testis. Choi YJ, et al. Theriogenology, 2010 Feb. PMID 19913896
  2. Characterization of MORN2 stability and regulatory function in LC3-associated phagocytosis in macrophages. Morita M, et al. Biol Open, 2020 Jun 23. PMID 32414768, Free PMC Article
  3. Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein Required for Meiotic Crossing Over in Mice, as an E3 SUMO Ligase. Strong ER, et al. Genes (Basel), 2010 Dec 2. PMID 21779533, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MORN2 regulates the morphology and energy metabolism of mitochondria and is required for male fertility in mice.
    Title: MORN2 regulates the morphology and energy metabolism of mitochondria and is required for male fertility in mice.
  2. Characterization of MORN2 stability and regulatory function in LC3-associated phagocytosis in macrophages.
    Title: Characterization of MORN2 stability and regulatory function in LC3-associated phagocytosis in macrophages.
  3. MOPT is associated with dynamic regulation of acrosome biogenesis during late spermiogenesis.
    Title: Identification and characterization of a novel mouse and human MOPT gene containing MORN-motif protein in testis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC107136

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MORN repeat-containing protein 2
Names
MORN motif protein in testis
protein containing single MORN motif in testis

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360440.2 → NP_001347369.1  MORN repeat-containing protein 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC132910
    Consensus CDS
    CCDS37703.1
    UniProtKB/Swiss-Prot
    Q6UL01
    Conserved Domains (1) summary
    COG4642
    Location:1 → 72
    COG4642; Uncharacterized conserved protein [Function unknown]

  2. NM_001413767.1 → NP_001400696.1  MORN repeat-containing protein 2

    Status: VALIDATED

    Source sequence(s)
    AC132910
    UniProtKB/Swiss-Prot
    Q6UL01

  3. NM_194269.3 → NP_919245.1  MORN repeat-containing protein 2

    See identical proteins and their annotated locations for NP_919245.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC132910
    Consensus CDS
    CCDS37703.1
    UniProtKB/Swiss-Prot
    Q6UL01
    Related
    ENSMUSP00000051408.10, ENSMUST00000061703.10
    Conserved Domains (1) summary
    COG4642
    Location:1 → 72
    COG4642; Uncharacterized conserved protein [Function unknown]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    80597626..80613130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160655.1 → XP_036016548.1  MORN repeat-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6UL01
    Conserved Domains (1) summary
    COG4642
    Location:1 → 72
    COG4642; Uncharacterized conserved protein [Function unknown]

  2. XM_036160656.1 → XP_036016549.1  MORN repeat-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6UL01
    Conserved Domains (1) summary
    COG4642
    Location:1 → 72
    COG4642; Uncharacterized conserved protein [Function unknown]

  3. XM_036160654.1 → XP_036016547.1  MORN repeat-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6UL01
    Conserved Domains (1) summary
    COG4642
    Location:1 → 72
    COG4642; Uncharacterized conserved protein [Function unknown]

  4. XM_036160657.1 → XP_036016550.1  MORN repeat-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6UL01
    Conserved Domains (1) summary
    COG4642
    Location:1 → 72
    COG4642; Uncharacterized conserved protein [Function unknown]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UL01.1 GenPept UniProtKB/Swiss-Prot:Q6UL01

Gene LinkOut

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