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BGLF4 tegument serine/threonine protein kinase [ Human gammaherpesvirus 4 (Epstein-Barr virus) ]

Gene ID: 3783704, updated on 20-Nov-2023

Summary

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Gene symbol
BGLF4
Gene description
tegument serine/threonine protein kinase
Locus tag
HHV4_BGLF4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human gammaherpesvirus 4 (strain: B95-8, strain: Raji, type: 1, common: Epstein-Barr virus, acronym: EBV, acronym: HHV-4, nat-host: Homo sapiens)
Lineage
Viruses; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus
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Genomic context

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Sequence:
NC_007605.1 (108459..111326, complement)

NC_007605.1Genomic Context describing neighboring genes Neighboring gene capsid portal protein Neighboring gene helicase-primase subunit Neighboring gene tegument protein UL7 Neighboring gene envelope glycoprotein M Neighboring gene tegument protein UL14 Neighboring gene protein UL95 Neighboring gene deoxyribonuclease Neighboring gene myristylated tegument protein Neighboring gene DNA packaging terminase subunit 1 Neighboring gene protein UL91 Neighboring gene tegument protein UL16 Neighboring gene DNA packaging tegument protein UL17 Neighboring gene protein UL92 Neighboring gene envelope glycoprotein 150 Neighboring gene envelope glycoprotein 48 Neighboring gene capsid triplex subunit 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007605.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Key motifs in EBV (Epstein-Barr virus)-encoded protein kinase for phosphorylation activity and nuclear localization. Gershburg S, et al. Biochem J, 2010 Oct 15. PMID 20704565, Free PMC Article
  2. Characterization of Epstein-Barr virus BGLF4 kinase expression control at the transcriptional and translational levels. Wang JT, et al. J Gen Virol, 2010 Sep. PMID 20444992
  3. Efficient production of infectious viruses requires enzymatic activity of Epstein-Barr virus protein kinase. Murata T, et al. Virology, 2009 Jun 20. PMID 19427010
  4. Protein array identification of substrates of the Epstein-Barr virus protein kinase BGLF4. Zhu J, et al. J Virol, 2009 May. PMID 19244323, Free PMC Article
  5. Epstein-Barr virus BGLF4 kinase suppresses the interferon regulatory factor 3 signaling pathway. Wang JT, et al. J Virol, 2009 Feb. PMID 19052084, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results identify the EBV early lytic gene BGLF4-encoded viral protein kinase as a candidate that enhances expression of the viral latency-to-lytic switch protein ZEBRA.
    Title: Retrograde Regulation by the Viral Protein Kinase Epigenetically Sustains the Epstein-Barr Virus Latency-to-Lytic Switch To Augment Virus Production.
  2. The region of aa 250-295 of BGLF4 is essential for the BGLF4/Hsp90 interaction.
    Title: The split Renilla luciferase complementation assay is useful for identifying the interaction of Epstein-Barr virus protein kinase BGLF4 and a heat shock protein Hsp90.
  3. findings reveal the presence of a late control locus encompassing BGLF3 and BGLF4 in the Epstein-Barr virus genome
    Title: A locus encompassing the Epstein-Barr virus bglf4 kinase regulates expression of genes encoding viral structural proteins.
  4. The data presented here suggest that BGLF4 interferes with the normal functions of Nup62 and Nup153 and preferentially helps the nuclear import of viral proteins for viral DNA replication and assembly.
    Title: BGLF4 kinase modulates the structure and transport preference of the nuclear pore complex to facilitate nuclear import of Epstein-Barr virus lytic proteins.
  5. Epstein-Barr virus BGLF4 kinase downregulates NF-kappaB transactivation through phosphorylation of coactivator UXT
    Title: Epstein-Barr virus BGLF4 kinase downregulates NF-κB transactivation through phosphorylation of coactivator UXT.
  6. BGLF4 may directly or indirectly induce a DNA damage signal that eventually interferes with host DNA synthesis and delays S-phase progression.
    Title: Epstein-Barr virus BGLF4 kinase retards cellular S-phase progression and induces chromosomal abnormality.
  7. SUMO2 binding by the Epstein-Barr virus protein kinase BGLF4 is crucial for BGLF4 function.
    Title: SUMO binding by the Epstein-Barr virus protein kinase BGLF4 is crucial for BGLF4 function.
  8. During Epstein-Barr virus replication, TIP60 activation by the BGLF4 kinase triggers Epstein-Barr virus-induced DNA damage response and also mediates induction of viral lytic gene expression.
    Title: Conserved herpesvirus kinases target the DNA damage response pathway and TIP60 histone acetyltransferase to promote virus replication.
  9. Site-directed mutagenesis has been employed to generate mutations targeting residues involved in nuclear localization of the EBV-PK.
    Title: Key motifs in EBV (Epstein-Barr virus)-encoded protein kinase for phosphorylation activity and nuclear localization.
  10. different promoter usage and 5'UTR-mediated translation enhancement may ensure the proper expression of BGLF4 at various stages of virus replication
    Title: Characterization of Epstein-Barr virus BGLF4 kinase expression control at the transcriptional and translational levels.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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regulatory

  • Loc: c108476-108471 regulatory_class = polyA_signal_sequence
  • Loc: c109043-109038 regulatory_class = TATA_box

General protein information

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Preferred Names
tegument serine/threonine protein kinase
YP_401688.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007605.1 Reference assembly

    Range
    108459..111326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_401688.1 tegument serine/threonine protein kinase [Human gammaherpesvirus 4]

    See identical proteins and their annotated locations for YP_401688.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0C6Z8, P0C731, P13288, Q777D1
    UniProtKB/TrEMBL
    A0A0B6VIN4, A0A0C7SWT0, A0A0C7TGU5, A0A0C7TP13, A0A191T7D0, A0A2S1MXZ3, A0A2S1N131, A0A2S1N1Q7, A0A385JC55, A0A3R5TWR8, A0A3R5WU81, A0A3R5XDZ6, A0A410IR94, A0A482DL71, I1YP37
    Conserved Domains (1) summary
    cl21453
    Location:84 → 241
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C731.1

Gene LinkOut

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