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BALF5 DNA polymerase catalytic subunit [ Human gammaherpesvirus 4 (Epstein-Barr virus) ]

Gene ID: 3783681, updated on 20-Nov-2023

Summary

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Gene symbol
BALF5
Gene description
DNA polymerase catalytic subunit
Locus tag
HHV4_BALF5
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human gammaherpesvirus 4 (strain: B95-8, strain: Raji, type: 1, common: Epstein-Barr virus, acronym: EBV, acronym: HHV-4, nat-host: Homo sapiens)
Lineage
Viruses; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus
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Genomic context

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Sequence:
NC_007605.1 (151372..156288, complement)

NC_007605.1Genomic Context describing neighboring genes Neighboring gene protein RPMS1 Neighboring gene protein LF3 Neighboring gene membrane protein BILF1 Neighboring gene virion protein G11 Neighboring gene protein G10 Neighboring gene protein A73 Neighboring gene envelope glycoprotein B Neighboring gene DNA packaging terminase subunit 2 Neighboring gene protein BARF0 Neighboring gene single-stranded DNA-binding protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007605.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Efficient Translation of Epstein-Barr Virus (EBV) DNA Polymerase Contributes to the Enhanced Lytic Replication Phenotype of M81 EBV. Church TM, et al. J Virol, 2018 Mar 15. PMID 29263273, Free PMC Article
  2. Epstein-Barr virus-encoded microRNA miR-BART2 down-regulates the viral DNA polymerase BALF5. Barth S, et al. Nucleic Acids Res, 2008 Feb. PMID 18073197, Free PMC Article
  3. Pin1 interacts with the Epstein-Barr virus DNA polymerase catalytic subunit and regulates viral DNA replication. Narita Y, et al. J Virol, 2013 Feb. PMID 23221557, Free PMC Article
  4. Nuclear transport of Epstein-Barr virus DNA polymerase is dependent on the BMRF1 polymerase processivity factor and molecular chaperone Hsp90. Kawashima D, et al. J Virol, 2013 Jun. PMID 23552409, Free PMC Article
  5. The Epstein-Barr virus pol catalytic subunit physically interacts with the BBLF4-BSLF1-BBLF2/3 complex. Fujii K, et al. J Virol, 2000 Mar. PMID 10684269, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ATM, KAP1 and the Epstein-Barr virus polymerase processivity factor direct traffic at the intersection of transcription and replication.
    Title: ATM, KAP1 and the Epstein-Barr virus polymerase processivity factor direct traffic at the intersection of transcription and replication.
  2. This study examines potential causes of the enhanced lytic replicative properties of M81 EBV isolated from a nasopharyngeal carcinoma (NPC) patient and provides new evidence for the role of the BALF5 gene 3' UTR sequence in DNA polymerase protein expression during lytic replication. Variation in the gene structure of the DNA polymerase gene may therefore contribute to lytic virus reactivation and pathogenesis.
    Title: Efficient Translation of Epstein-Barr Virus (EBV) DNA Polymerase Contributes to the Enhanced Lytic Replication Phenotype of M81 EBV.
  3. Nuclear transport of BALF5 is dependent on the BMRF1 polymerase processivity factor and host molecular chaperone Hsp90.
    Title: Nuclear transport of Epstein-Barr virus DNA polymerase is dependent on the BMRF1 polymerase processivity factor and molecular chaperone Hsp90.
  4. Authors found that Epstein-Barr virus DNA polymerase BALF5 subunit interacts with Pin1 through BALF5 Thr178 in a phosphorylation-dependent manner.
    Title: Pin1 interacts with the Epstein-Barr virus DNA polymerase catalytic subunit and regulates viral DNA replication.
  5. The microRNA MiR-BART2 guides cleavage within the 3'-untranslated region of BALF5 by virtue of its complete complementarity to its target.
    Title: Epstein-Barr virus-encoded microRNA miR-BART2 down-regulates the viral DNA polymerase BALF5.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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regulatory

  • Loc: c156249-156244 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
DNA polymerase catalytic subunit
YP_401712.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007605.1 Reference assembly

    Range
    151372..156288 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_401712.1 DNA polymerase catalytic subunit [Human gammaherpesvirus 4]

    See identical proteins and their annotated locations for YP_401712.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P03198, Q777B1
    UniProtKB/TrEMBL
    A0A0B6VKV3, A0A0C7T056, A0A0C7T5N1, A0A0C7TUF4, A0A0C7TZN1, A0A2S1MNE9, A0A2S1MPC6, A0A2S1MPX4, A0A2S1MUM5, A0A2S1MVG6, A0A3R5TVN7, A0A410HZ60, A0A410IE10
    Conserved Domains (2) summary
    pfam00136
    Location:523 → 994
    DNA_pol_B; DNA polymerase family B
    pfam03104
    Location:136 → 459
    DNA_pol_B_exo1; DNA polymerase family B, exonuclease domain
Nucleotide Protein
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