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PHDP Putative homeodomain protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37788, updated on 2-Nov-2024

Summary

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Official Symbol
PHDPprovided by FlyBase
Official Full Name
Putative homeodomain proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0025334
Locus tag
Dmel_CG11182
See related
AllianceGenome:FB:FBgn0025334
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-60Ac; CG11182; Dmel\CG11182
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in embryonic brain and larval ventral nerve cord. Human ortholog(s) of this gene implicated in colorectal cancer; congenital central hypoventilation syndrome; congenital fibrosis of the extraocular muscles 2; and neuroblastoma. Orthologous to several human genes including PHOX2B (paired like homeobox 2B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See PHDP in Genome Data Viewer
Location:
60A7-60A8; 2-105 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23883136..23884440, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19770659..19771963, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ken and barbie Neighboring gene Transmembrane 4 superfamily Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Decapping protein 1 Neighboring gene DNA ligase 1 Neighboring gene Upf3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Post-transcriptional modulation of cytochrome P450s, Cyp6g1 and Cyp6g2, by miR-310s cluster is associated with DDT-resistant Drosophila melanogaster strain 91-R. Seong KM, et al. Sci Rep, 2020 Sep 1. PMID 32873850, Free PMC Article
  2. The Drosophila melanogaster 60A chromosomal division is extremely dense with functional genes: their sequences, genomic organization, and expression. Lukacsovich T, et al. Genomics, 1999 Apr 1. PMID 10191082
  3. Pax3/7 genes reveal conservation and divergence in the arthropod segmentation hierarchy. Davis GK, et al. Dev Biol, 2005 Sep 1. PMID 16083872
  4. Evolution of homeobox genes: Q50 Paired-like genes founded the Paired class. Galliot B, et al. Dev Genes Evol, 1999 Mar. PMID 10079362
  5. Homeobox gene clusters and the human paralogy map. Popovici C, et al. FEBS Lett, 2001 Mar 2. PMID 11240134

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative homeodomain protein
Names
CG11182-PA
PHDP-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23883136..23884440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079110.3 → NP_523834.1  putative homeodomain protein [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523834.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0IGW1, Q9W1H7
    Related
    FBpp0072133
    Conserved Domains (1) summary
    pfam00046
    Location:116 → 168
    Homeobox; Homeobox domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O76136 O76136
Q9W1H7 Q9W1H7

Gene LinkOut

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