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Nxt1 NTF2-related export protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37769, updated on 2-Nov-2024

Summary

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Official Symbol
Nxt1provided by FlyBase
Official Full Name
NTF2-related export protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0028411
Locus tag
Dmel_CG12752
See related
AllianceGenome:FB:FBgn0028411
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12752; Dmel\CG12752; dmNXT; dmNXT1; DmNXT1; dmP15; dNxt; dNxt1; Nxt; Nxt-1; nxt1; NXT1; p15
Summary
Involved in poly(A)+ mRNA export from nucleus. Located in cytoplasm; nuclear envelope; and nucleoplasm. Part of transcription repressor complex. Is expressed in several structures, including antennal primordium; embryonic/larval midgut primordium; gut section; head epidermis primordium; and mesoderm. Orthologous to human NXT1 (nuclear transport factor 2 like export factor 1) and NXT2 (nuclear transport factor 2 like export factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Nxt1 in Genome Data Viewer
Location:
60A2-60A2; 2-105 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23811321..23811974, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19698844..19699497, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Structure specific recognition protein Neighboring gene antisense RNA:CR44807 Neighboring gene uncharacterized protein Neighboring gene pippin Neighboring gene Glycine transporter Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Unravelling the general properties of siRNAs: strength in numbers and lessons from the past. Hall J. Nat Rev Genet, 2004 Jul. PMID 15211357
  2. Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes. Wiegand HL, et al. Mol Cell Biol, 2002 Jan. PMID 11739738, Free PMC Article
  3. RNA-binding proteins of the NXF (nuclear export factor) family and their connection with the cytoskeleton. Mamon LA, et al. Cytoskeleton (Hoboken), 2017 Apr. PMID 28296067
  4. Nuclear export of mRNA by TAP/NXF1 requires two nucleoporin-binding sites but not p15. Braun IC, et al. Mol Cell Biol, 2002 Aug. PMID 12101235, Free PMC Article
  5. MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. Zeng Y, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12902540, Free PMC Article

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium HMP PubMed 
involved_in negative regulation of innate immune response HMP PubMed 
involved_in nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
  
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in poly(A)+ mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pore central transport channel IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription repressor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
NTF2-related export protein 1
Names
CG12752-PA
CG12752-PB
Nxt1-PA
Nxt1-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23811321..23811974 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137989.3 → NP_611833.1  NTF2-related export protein 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611833.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V3H8
    UniProtKB/TrEMBL
    A0A1B2AKG3
    Related
    FBpp0072150
    Conserved Domains (1) summary
    cd00780
    Location:11 → 132
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

  2. NM_001299854.1 → NP_001286783.1  NTF2-related export protein 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286783.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGG9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LGG9 A0A0B4LGG9
Q9V3H8.1 Q9V3H8

Gene LinkOut

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