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Alg3 ALG3, alpha-1,3- mannosyltransferase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37754, updated on 2-Nov-2024

Summary

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Official Symbol
Alg3provided by FlyBase
Official Full Name
ALG3, alpha-1,3- mannosyltransferaseprovided by FlyBase
Primary source
FLYBASE:FBgn0011297
Locus tag
Dmel_CG4084
See related
AllianceGenome:FB:FBgn0011297
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
1(2) not; alg3; ALG3; cDNA 10F; CG4084; dAlg3; Dmel\CG4084; l(2)not; L(2)NOT; l(2)td; l(2)tid; l(2)tud; NOT; ntid; tid
Summary
Predicted to enable dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity. Involved in negative regulation of tumor necrosis factor-mediated signaling pathway. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Id. Orthologous to human ALG3 (ALG3 alpha-1,3- mannosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See Alg3 in Genome Data Viewer
Location:
59F6-59F6; 2-104 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23705439..23709792, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19592962..19597315, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L43 Neighboring gene salivary glands marred Neighboring gene lethal-(2)-denticleless Neighboring gene antisense RNA:CR45326 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Sestrin Neighboring gene long non-coding RNA:CR45325 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic, cytogenetic and developmental analysis of the Drosophila melanogaster tumor suppressor gene lethal(2)tumorous imaginal discs (1(2)tid). Kurzik-Dumke U, et al. Differentiation, 1992 Oct. PMID 1473626
  2. Sequential cleavage of the proteins encoded by HNOT/ALG3, the human counterpart of the Drosophila NOT and yeast ALG3 gene, results in products acting in distinct cellular compartments. Hacker B, et al. Hum Mol Genet, 2018 Dec 15. PMID 30192950
  3. Mitochondrial localization and temporal expression of the Drosophila melanogaster DnaJ homologous tumor suppressor Tid50. Kurzik-Dumke U, et al. Cell Stress Chaperones, 1998 Mar. PMID 9585178, Free PMC Article
  4. Gene within gene configuration and expression of the Drosophila melanogaster genes lethal(2) neighbour of tid [l(2)not] and lethal(2) relative of tid[l(2)rot]. Kurzik-Dumke U, et al. Gene, 1997 Oct 24. PMID 9373138
  5. Tumor suppression in Drosophila is causally related to the function of the lethal(2) tumorous imaginal discs gene, a dnaJ homolog. Kurzik-Dumke U, et al. Dev Genet, 1995. PMID 7758246

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ALG3, alpha-1,3- mannosyltransferase
Names
Alg3-PA
Asparagine-Linked Glycosylation-3
CG4084-PA
alpha1,3-mannosyltransferase
l(2)tumorous disc
l(2)tumorous imaginal discs
lethal (2) neighbor of tid
lethal(2) neighbour of 1(2)tid
lethal(2) tumorous imaginal discs
lethal(2)neighbour of tid
lethal(2)tumorous imaginal discs
tumorous imaginal disc
NP_523829.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23705439..23709792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079105.4 → NP_523829.2  ALG3, alpha-1,3- mannosyltransferase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523829.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O02532, O02533, Q24419, Q24420, Q24421, Q24607, Q27333, Q95R76, Q9W1K8
    UniProtKB/TrEMBL
    C4IXX8
    Related
    FBpp0072004
    Conserved Domains (1) summary
    pfam05208
    Location:51 → 470
    ALG3; ALG3 protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P82149.1 P82149
Q27333.1 Q27333

Gene LinkOut

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