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angel angel [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37748, updated on 18-Sep-2024

Summary

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Official Symbol
angelprovided by FlyBase
Official Full Name
angelprovided by FlyBase
Primary source
FLYBASE:FBgn0016762
Locus tag
Dmel_CG12273
See related
AllianceGenome:FB:FBgn0016762
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Angel; CG1227; CG12273; DmAngel; Dmel\CG12273
Summary
Predicted to enable 3'-5'-exoribonuclease activity. Is expressed in organism. Orthologous to several human genes including ANGEL1 (angel homolog 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See angel in Genome Data Viewer
Location:
59F6-59F6; 2-104 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23694003..23695232)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19581526..19582755)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Sulfotransferase 3 Neighboring gene lethal (2) essential for life Neighboring gene Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 2 Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L43 Neighboring gene salivary glands marred Neighboring gene lethal-(2)-denticleless

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a novel Drosophila melanogaster gene, angel, a member of a nested gene cluster at locus 59F4,5. Kurzik-Dumke U, et al. Biochim Biophys Acta, 1996 Sep 11. PMID 8809105
  2. twin, a CCR4 homolog, regulates cyclin poly(A) tail length to permit Drosophila oogenesis. Morris JZ, et al. Development, 2005 Mar. PMID 15703281
  3. Cross-species genetic screens identify transglutaminase 5 as a regulator of polyglutamine-expanded ataxin-1. Lee WS, et al. J Clin Invest, 2022 May 2. PMID 35499073, Free PMC Article
  4. Kc167, a widely used Drosophila cell line, contains an active primary piRNA pathway. Vrettos N, et al. RNA, 2017 Jan. PMID 27789612, Free PMC Article
  5. Subunits of the Drosophila CCR4-NOT complex and their roles in mRNA deadenylation. Temme C, et al. RNA, 2010 Jul. PMID 20504953, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitochondrial mRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
angel
Names
CG12273-PA
DmAngel
angel-PA
NP_477204.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23694003..23695232
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057856.5 → NP_477204.1  angel [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477204.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24239, Q9W1L3
    Related
    FBpp0071992
    Conserved Domains (1) summary
    cl00490
    Location:70 → 351
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24239.2 Q24239

Gene LinkOut

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