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Eglp4 Entomoglyceroporin 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37739, updated on 28-Oct-2024

Summary

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Official Symbol
Eglp4provided by FlyBase
Official Full Name
Entomoglyceroporin 4provided by FlyBase
Primary source
FLYBASE:FBgn0034885
Locus tag
Dmel_CG4019
See related
AllianceGenome:FB:FBgn0034885
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Aqp4019; CG4019; Dmel\CG4019; Eglp 4
Summary
Predicted to enable channel activity. Involved in renal system process. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including adult head; adult heart; apoptotic amnioserosa; embryonic anal pad; and muscle cell. Orthologous to human AQP8 (aquaporin 8). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

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See Eglp4 in Genome Data Viewer
Location:
59F4-59F4; 2-104 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23607592..23614710, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19495115..19502233, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Entomoglyceroporin 1 Neighboring gene Entomoglyceroporin 2 Neighboring gene Entomoglyceroporin 3 Neighboring gene long non-coding RNA:CR45153 Neighboring gene retained Neighboring gene Phosphodiesterase 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Developmental expression and biophysical characterization of a Drosophila melanogaster aquaporin. Kaufmann N, et al. Am J Physiol Cell Physiol, 2005 Aug. PMID 15800049
  2. Insect glycerol transporters evolved by functional co-option and gene replacement. Finn RN, et al. Nat Commun, 2015 Jul 17. PMID 26183829, Free PMC Article
  3. Specialized stellate cells offer a privileged route for rapid water flux in Drosophila renal tubule. Cabrero P, et al. Proc Natl Acad Sci U S A, 2020 Jan 21. PMID 31907321, Free PMC Article
  4. Genetic mapping with SNP markers in Drosophila. Berger J, et al. Nat Genet, 2001 Dec. PMID 11726933
  5. Transporters and tubule crystals in the insect Malpighian tubule. Reynolds CJ, et al. Curr Opin Insect Sci, 2021 Oct. PMID 34044181, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables channel activity IEA
Inferred from Electronic Annotation
more info
  
enables channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in renal system process IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
entomoglyceroporin 4
Names
CG4019-PA
CG4019-PB
CG4019-PC
CG4019-PD
CG4019-PE
CG4019-PF
Eglp4-PA
Eglp4-PB
Eglp4-PC
Eglp4-PD
Eglp4-PE
Eglp4-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23607592..23614710 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137969.3 → NP_611813.1  entomoglyceroporin 4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611813.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NR72
    Related
    FBpp0072011
    Conserved Domains (1) summary
    cl00200
    Location:11 → 224
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

  2. NM_166615.3 → NP_726349.1  entomoglyceroporin 4, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726349.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NR72
    Related
    FBpp0072012
    Conserved Domains (1) summary
    cl00200
    Location:11 → 224
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

  3. NM_166614.2 → NP_726348.1  entomoglyceroporin 4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726348.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NR72
    Related
    FBpp0072013
    Conserved Domains (1) summary
    cl00200
    Location:11 → 224
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

  4. NM_166613.2 → NP_726347.1  entomoglyceroporin 4, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726347.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MLR2
    Related
    FBpp0072014
    Conserved Domains (1) summary
    cl00200
    Location:23 → 236
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

  5. NM_001259553.1 → NP_001246482.1  entomoglyceroporin 4, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246482.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D1Z394
    Conserved Domains (1) summary
    cl00200
    Location:48 → 261
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

  6. NM_001274225.1 → NP_001261154.1  entomoglyceroporin 4, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261154.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFZ1
    Conserved Domains (1) summary
    cl00200
    Location:59 → 272
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFZ1 A0A0B4KFZ1
D1Z394 D1Z394
Q6NR72 Q6NR72
Q8MLR2 Q8MLR2

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