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pita pita [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37730, updated on 2-Nov-2024

Summary

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Official Symbol
pitaprovided by FlyBase
Official Full Name
pitaprovided by FlyBase
Primary source
FLYBASE:FBgn0034878
Locus tag
Dmel_CG3941
See related
AllianceGenome:FB:FBgn0034878
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3941; Dmel\CG3941; Pita; PITA; spdk
Summary
Enables chromatin insulator sequence binding activity and sequence-specific DNA binding activity. Involved in DNA endoreduplication and regulation of DNA-templated transcription. Located in nucleus and polytene chromosome. Is expressed in several structures, including CNS glial cell; ganglia; head epidermis primordium; somatic precursor cell; and unpaired neurons. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See pita in Genome Data Viewer
Location:
59E3-59E3; 2-103 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23548967..23554712, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19436490..19442235, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Gustatory receptor 59f Neighboring gene aaRS-interacting multifunctional protein 3 Neighboring gene wing morphogenesis defect Neighboring gene levy Neighboring gene Death caspase-1 Neighboring gene Rrp4 Neighboring gene Integrin alphaPS5 subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Morphological irregularities and features of resistance to apoptosis in the dcp-1/pita double mutated egg chambers during Drosophila oogenesis. Nezis IP, et al. Cell Motil Cytoskeleton, 2005 Jan. PMID 15547953
  2. Germline cell death is inhibited by P-element insertions disrupting the dcp-1/pita nested gene pair in Drosophila. Laundrie B, et al. Genetics, 2003 Dec. PMID 14704173, Free PMC Article
  3. Redundant enhancers in the iab-5 domain cooperatively activate Abd-B in the A5 and A6 abdominal segments of Drosophila. Postika N, et al. Development, 2021 Oct 1. PMID 34473267, Free PMC Article
  4. Architectural protein Pita cooperates with dCTCF in organization of functional boundaries in Bithorax complex. Kyrchanova O, et al. Development, 2017 Jul 15. PMID 28619827, Free PMC Article
  5. Lineage-specific expansion of the zinc finger associated domain ZAD. Chung HR, et al. Mol Biol Evol, 2007 Sep. PMID 17569752

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mechanism and functional role of the interaction between CP190 and the architectural protein Pita in Drosophila melanogaster.
    Title: Mechanism and functional role of the interaction between CP190 and the architectural protein Pita in Drosophila melanogaster.
  2. Mutation of the Mcp Pita site disrupts blocking activity and also eliminates dCTCF binding. In contrast, mutation of the Mcp dCTCF site does not affect Pita binding, and this mutant boundary retains partial function.
    Title: Architectural protein Pita cooperates with dCTCF in organization of functional boundaries in Bithorax complex.
  3. Here we have shown that the ZAD domains of ZIPIC, Pita and Zw5 form homodimers. In Drosophila transgenic lines, these proteins are able to support long-distance interaction between GAL4 activator and the reporter gene promoter.
    Title: Architectural proteins Pita, Zw5,and ZIPIC contain homodimerization domain and support specific long-range interactions in Drosophila.
  4. Model binding sites for Pita or ZIPIC demonstrate a partial enhancer-blocking activity and protect gene expression from PRE-mediated silencing.
    Title: Two new insulator proteins, Pita and ZIPIC, target CP190 to chromatin.
  5. novel characteristic morphological features of egg chambers lacking both dcp-1 and pita functions in the germline cells; suggested an essential role of dcp-1 and/or pita during mid-oogenesis
    Title: Morphological irregularities and features of resistance to apoptosis in the dcp-1/pita double mutated egg chambers during Drosophila oogenesis.
  6. Spotted-dick is a zinc-finger protein of Drosophila required for expression of Orc4 and S phase.
    Title: Spotted-dick, a zinc-finger protein of Drosophila required for expression of Orc4 and S phase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin insulator sequence binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA endoreduplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in polytene chromosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
pita
Names
CG3941-PA
CG3941-PB
pita-PA
pita-PB
spotted dick

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23548967..23554712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137962.3 → NP_611806.3  pita, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611806.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95RQ8, Q9W1N1
    Related
    FBpp0072021
    Conserved Domains (6) summary
    smart00868
    Location:17 → 92
    zf-AD; Zinc-finger associated domain (zf-AD)
    COG5048
    Location:281 → 506
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:288 → 308
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:372 → 388
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:328 → 353
    zf-H2C2_2; Zinc-finger double domain
    cl01319
    Location:566 → 625
    HARE-HTH; HB1, ASXL, restriction endonuclease HTH domain

  2. NM_166607.2 → NP_726339.2  pita, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726339.2

    Status: REVIEWED

    Related
    FBpp0072022
    Conserved Domains (5) summary
    COG5048
    Location:221 → 446
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:228 → 248
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam07776
    Location:1 → 33
    zf-AD; Zinc-finger associated domain (zf-AD)
    pfam13465
    Location:268 → 293
    zf-H2C2_2; Zinc-finger double domain
    cl01319
    Location:506 → 565
    HARE-HTH; HB1, ASXL, restriction endonuclease HTH domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95RQ8 Q95RQ8
Q95RQ8.1
Q9W1N1 Q9W1N1

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