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wmd wing morphogenesis defect [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37727, updated on 22-Aug-2024

Summary

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Official Symbol
wmdprovided by FlyBase
Official Full Name
wing morphogenesis defectprovided by FlyBase
Primary source
FLYBASE:FBgn0034876
Locus tag
Dmel_CG3957
See related
AllianceGenome:FB:FBgn0034876
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3957; CG3957/wmd; Dmel\CG3957; pter; Unrip; WMD
Summary
Involved in imaginal disc-derived wing morphogenesis. Is expressed in anterior midgut primordium; head mesoderm; organism; posterior midgut primordium; and trunk mesoderm. Human ortholog(s) of this gene implicated in adenocarcinoma; colorectal carcinoma; large cell carcinoma; lung carcinoma; and squamous cell neoplasm. Orthologous to human STRAP (serine/threonine kinase receptor associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See wmd in Genome Data Viewer
Location:
59E3-59E3; 2-103 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23544823..23548151, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19432346..19435674, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Gustatory receptor 59e Neighboring gene Gustatory receptor 59f Neighboring gene aaRS-interacting multifunctional protein 3 Neighboring gene levy Neighboring gene pita Neighboring gene Death caspase-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Disruption of snRNP biogenesis factors Tgs1 and pICln induces phenotypes that mirror aspects of SMN-Gemins complex perturbation in Drosophila, providing new insights into spinal muscular atrophy. Borg RM, et al. Neurobiol Dis, 2016 Oct. PMID 27388936
  2. Mutations in cytochrome c oxidase subunit VIa cause neurodegeneration and motor dysfunction in Drosophila. Liu W, et al. Genetics, 2007 Jun. PMID 17435251, Free PMC Article
  3. Disruption of Survival Motor Neuron in Glia Impacts Survival but has no Effect on Neuromuscular Function in Drosophila. Farrugia M, et al. Neuroscience, 2022 May 21. PMID 35314252
  4. Novel interactors of the Drosophila Survival Motor Neuron (SMN) Complex suggest its full conservation. Lanfranco M, et al. FEBS Lett, 2017 Nov. PMID 28949413
  5. Sequence elements in cis influence heterochromatic silencing in trans. Sage BT, et al. Mol Cell Biol, 2005 Jan. PMID 15601858, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spliceosomal snRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SMN complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
wing morphogenesis defect
Names
CG3957-PA
CG3957-PB
pterodactyl
wmd-PA
wmd-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23544823..23548151 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103966.2 → NP_001097436.1  wing morphogenesis defect, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W1N4
    Conserved Domains (2) summary
    cd00200
    Location:12 → 297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:108 → 144
    7WD40; WD40 repeat [structural motif]

  2. NM_137960.3 → NP_611804.1  wing morphogenesis defect, isoform A [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W1N4
    Related
    FBpp0072023
    Conserved Domains (2) summary
    cd00200
    Location:12 → 297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:108 → 144
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W1N4 Q9W1N4

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