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KCNJ15 potassium inwardly rectifying channel subfamily J member 15 [ Homo sapiens (human) ]

Gene ID: 3772, updated on 5-Mar-2024

Summary

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Official Symbol
KCNJ15provided by HGNC
Official Full Name
potassium inwardly rectifying channel subfamily J member 15provided by HGNC
Primary source
HGNC:HGNC:6261
See related
Ensembl:ENSG00000157551 MIM:602106; AllianceGenome:HGNC:6261
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IRKK; KIR1.3; KIR4.2
Summary
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013]
Expression
Biased expression in kidney (RPKM 38.5), thyroid (RPKM 23.6) and 6 other tissues See more
Orthologs
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Genomic context

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Location:
21q22.13-q22.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (38229926..38307357)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (36613403..36690781)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (39601848..39679279)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene cutaneous T cell lymphoma-associated antigen 1 pseudogene Neighboring gene Down syndrome critical region 10 Neighboring gene Sharpr-MPRA regulatory region 5297 Neighboring gene Sharpr-MPRA regulatory region 13169 Neighboring gene spermatogenesis associated 20 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18456 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18457 Neighboring gene uncharacterized LOC105372801 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13310 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13311 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr21:39649284-39650483 Neighboring gene long intergenic non-protein coding RNA 1423 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:39704626-39705825 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62068 Neighboring gene uncharacterized LOC107985513

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. KCNJ15 Expression and Malignant Behavior of Esophageal Squamous Cell Carcinoma. Nakamura S, et al. Ann Surg Oncol, 2020 Jul. PMID 32052303
  2. KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis. Nakajima KI, et al. Nat Commun, 2015 Oct 9. PMID 26449415, Free PMC Article
  3. Potassium channel KCNJ15 is required for histamine-stimulated gastric acid secretion. Yuan J, et al. Am J Physiol Cell Physiol, 2015 Aug 15. PMID 26108660
  4. Replication study for the association of a single-nucleotide polymorphism, rs3746876, within KCNJ15, with susceptibility to type 2 diabetes in a Japanese population. Fukuda H, et al. J Hum Genet, 2013 Jul. PMID 23595124
  5. Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus. Okamoto K, et al. Am J Hum Genet, 2010 Jan. PMID 20085713, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hunting for Familial Parkinson's Disease Mutations in the Post Genome Era.
    Title: Hunting for Familial Parkinson's Disease Mutations in the Post Genome Era.
  2. KCNJ15 Expression and Malignant Behavior of Esophageal Squamous Cell Carcinoma.
    Title: KCNJ15 Expression and Malignant Behavior of Esophageal Squamous Cell Carcinoma.
  3. KCNJ15 couples with polyamines in sensing weak electric fields.
    Title: KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis.
  4. RNA-seq evidence of biallelic expression of KCNJ15 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of KCNJ15 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB differentially methylated region (DMR) in disomic controls or trisomy (Down syndrome) individuals.
    Title: Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners.
  5. KCNJ15 has a major role in histamine-stimulated gastric acid secretion.
    Title: Potassium channel KCNJ15 is required for histamine-stimulated gastric acid secretion.
  6. We had performed a replication study using an independent larger Japanese population for the association of rs3746876 within KCNJ15, and observed a significant association of rs3746876 with type 2 diabetes, but this study failed to find original finding.
    Title: Replication study for the association of a single-nucleotide polymorphism, rs3746876, within KCNJ15, with susceptibility to type 2 diabetes in a Japanese population.
  7. It was shown that downregulation of Kcnj15 leads to increased insulin secretion in vitro and in vivo. The mechanism for regulating insulin secretion inolved a calcium-sensiong receptor.
    Title: Inhibition of glucose-stimulated insulin secretion by KCNJ15, a newly identified susceptibility gene for type 2 diabetes.
  8. Observational study of gene-disease association. (HuGE Navigator)
    Title: Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus.
  9. KCNJ15 is a previously unreported susceptibility gene for T2DM among Asians
    Title: Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus.
  10. MUPP1 and Kir4.2 may participate in a protein complex in the nephron that could regulate transport of K(+) as well as other ions.
    Title: MUPP1 complexes renal K+ channels to alter cell surface expression and whole cell currents.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC13584

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
ATP-sensitive inward rectifier potassium channel 15
Names
inward rectifier K(+) channel Kir1.3
inward rectifier K(+) channel Kir4.2
inward rectifier K+ channel KIR4.2
potassium channel, inwardly rectifying subfamily J member 15
potassium voltage-gated channel subfamily J member 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276435.2 → NP_001263364.1  ATP-sensitive inward rectifier potassium channel 15

    See identical proteins and their annotated locations for NP_001263364.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction and contains two additional exons in the 5' UTR compared to variant 1. All eight variants encode the same protein.
    Source sequence(s)
    AI344546, AI453386, AP001422, BC013327, DA968871
    Consensus CDS
    CCDS13656.1
    UniProtKB/Swiss-Prot
    D3DSH5, O00564, Q96L28, Q99446, Q99712
    UniProtKB/TrEMBL
    A8K9U7
    Related
    ENSP00000484960.1, ENST00000612702.4
    Conserved Domains (2) summary
    pfam01007
    Location:30 → 171
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:178 → 349
    IRK_C; Inward rectifier potassium channel C-terminal domain

  2. NM_001276436.2 → NP_001263365.1  ATP-sensitive inward rectifier potassium channel 15

    See identical proteins and their annotated locations for NP_001263365.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice junction and contains two additional exons in the 5' UTR compared to variant 1. All eight variants encode the same protein.
    Source sequence(s)
    AI344546, AI453386, AP001422, BC013327, DB232867
    Consensus CDS
    CCDS13656.1
    UniProtKB/Swiss-Prot
    D3DSH5, O00564, Q96L28, Q99446, Q99712
    UniProtKB/TrEMBL
    A8K9U7
    Related
    ENSP00000479100.1, ENST00000613499.4
    Conserved Domains (2) summary
    pfam01007
    Location:30 → 171
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:178 → 349
    IRK_C; Inward rectifier potassium channel C-terminal domain

  3. NM_001276437.2 → NP_001263366.1  ATP-sensitive inward rectifier potassium channel 15

    See identical proteins and their annotated locations for NP_001263366.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate splice junction and contains an additional exon in the 5' UTR compared to variant 1. All eight variants encode the same protein.
    Source sequence(s)
    AI344546, AI453386, AP001422, BC013327, DA670230, DA675388
    Consensus CDS
    CCDS13656.1
    UniProtKB/Swiss-Prot
    D3DSH5, O00564, Q96L28, Q99446, Q99712
    UniProtKB/TrEMBL
    A8K9U7
    Conserved Domains (2) summary
    pfam01007
    Location:30 → 171
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:178 → 349
    IRK_C; Inward rectifier potassium channel C-terminal domain

  4. NM_001276438.2 → NP_001263367.1  ATP-sensitive inward rectifier potassium channel 15

    See identical proteins and their annotated locations for NP_001263367.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has an alternate 5'-most exon in the 5' UTR compared to variant 1. All eight variants encode the same protein.
    Source sequence(s)
    AI344546, AI453386, AP001422, BC013327, DA673158, DA675388
    Consensus CDS
    CCDS13656.1
    UniProtKB/Swiss-Prot
    D3DSH5, O00564, Q96L28, Q99446, Q99712
    UniProtKB/TrEMBL
    A8K9U7
    Conserved Domains (2) summary
    pfam01007
    Location:30 → 171
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:178 → 349
    IRK_C; Inward rectifier potassium channel C-terminal domain

  5. NM_001276439.2 → NP_001263368.1  ATP-sensitive inward rectifier potassium channel 15

    See identical proteins and their annotated locations for NP_001263368.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) uses an alternate splice junction and contains an additional exon in the 5' UTR compared to variant 1. All eight variants encode the same protein.
    Source sequence(s)
    AI344546, AI453386, AP001422, BC013327, DA673158
    Consensus CDS
    CCDS13656.1
    UniProtKB/Swiss-Prot
    D3DSH5, O00564, Q96L28, Q99446, Q99712
    UniProtKB/TrEMBL
    A8K9U7
    Conserved Domains (2) summary
    pfam01007
    Location:30 → 171
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:178 → 349
    IRK_C; Inward rectifier potassium channel C-terminal domain

  6. NM_002243.5 → NP_002234.2  ATP-sensitive inward rectifier potassium channel 15

    See identical proteins and their annotated locations for NP_002234.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction and contains an additional exon in the 5' UTR compared to variant 1. All eight variants encode the same protein.
    Source sequence(s)
    AI344546, AI453386, AP001422, BC013327, DA968871
    Consensus CDS
    CCDS13656.1
    UniProtKB/Swiss-Prot
    D3DSH5, O00564, Q96L28, Q99446, Q99712
    UniProtKB/TrEMBL
    A8K9U7
    Related
    ENSP00000331698.3, ENST00000328656.8
    Conserved Domains (2) summary
    pfam01007
    Location:30 → 171
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:178 → 349
    IRK_C; Inward rectifier potassium channel C-terminal domain

  7. NM_170736.3 → NP_733932.1  ATP-sensitive inward rectifier potassium channel 15

    See identical proteins and their annotated locations for NP_733932.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All eight variants encode the same protein.
    Source sequence(s)
    AI344546, AI453386, AP001422, BC013327, D87291
    Consensus CDS
    CCDS13656.1
    UniProtKB/Swiss-Prot
    D3DSH5, O00564, Q96L28, Q99446, Q99712
    UniProtKB/TrEMBL
    A8K9U7
    Related
    ENSP00000381911.2, ENST00000398938.7
    Conserved Domains (2) summary
    pfam01007
    Location:30 → 171
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:178 → 349
    IRK_C; Inward rectifier potassium channel C-terminal domain

  8. NM_170737.3 → NP_733933.1  ATP-sensitive inward rectifier potassium channel 15

    See identical proteins and their annotated locations for NP_733933.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5'-most exon in the 5' UTR compared to variant 1. All eight variants encode the same protein.
    Source sequence(s)
    AI344546, AI453386, AP001422, BC013327, DA632853
    Consensus CDS
    CCDS13656.1
    UniProtKB/Swiss-Prot
    D3DSH5, O00564, Q96L28, Q99446, Q99712
    UniProtKB/TrEMBL
    A8K9U7
    Related
    ENSP00000381907.1, ENST00000398934.5
    Conserved Domains (2) summary
    pfam01007
    Location:30 → 171
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:178 → 349
    IRK_C; Inward rectifier potassium channel C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    38229926..38307357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    36613403..36690781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99712.2 GenPept UniProtKB/Swiss-Prot:Q99712

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