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waw waclaw [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3771960, updated on 18-Sep-2024

Summary

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Official Symbol
wawprovided by FlyBase
Official Full Name
waclawprovided by FlyBase
Primary source
FLYBASE:FBgn0024182
Locus tag
Dmel_CG1410
See related
AllianceGenome:FB:FBgn0024182
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-19Fb; CG1410; CG32527; Dmel\CG1410; tu2
Summary
Predicted to enable mitochondrial ribosome binding activity. Predicted to be involved in positive regulation of translation. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; adult integumentary system; and spermatozoon. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 40. Orthologous to human GUF1 (GTP binding elongation factor GUF1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See waw in Genome Data Viewer
Location:
19F5-19F6; 1-65 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21363028..21373145)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21234055..21244172)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene small optic lobes Neighboring gene Septin 1 Neighboring gene bobby sox Neighboring gene antisense RNA:CR45612 Neighboring gene antisense RNA:CR45611 Neighboring gene sluggish A Neighboring gene ncRNA Neighboring gene DEAD-box helicase 56

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The sluggish-A gene of Drosophila melanogaster is expressed in the nervous system and encodes proline oxidase, a mitochondrial enzyme involved in glutamate biosynthesis. Hayward DC, et al. Proc Natl Acad Sci U S A, 1993 Apr 1. PMID 8096642, Free PMC Article
  2. A green fluorescent protein enhancer trap screen in Drosophila photoreceptor cells. Mollereau B, et al. Mech Dev, 2000 May. PMID 10781948
  3. Data transferability from model organisms to human beings: insights from the functional genomics of the flightless region of Drosophila. Maleszka R, et al. Proc Natl Acad Sci U S A, 1998 Mar 31. PMID 9520435, Free PMC Article
  4. Investigating Developmental and Epileptic Encephalopathy Using Drosophila melanogaster. Takai A, et al. Int J Mol Sci, 2020 Sep 3. PMID 32899411, Free PMC Article
  5. Identification of Evolutionarily Conserved Nuclear Matrix Proteins and Their Prokaryotic Origins. Sureka R, et al. J Proteome Res, 2021 Jan 1. PMID 33289389

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables mitochondrial ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mitochondrial ribosome binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in positive regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
waclaw
Names
CG1410-PA
waw-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    21363028..21373145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001031918.2 → NP_001027089.1  waclaw [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027089.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O61347, Q9VRH6
    UniProtKB/TrEMBL
    X4YDX6
    Conserved Domains (6) summary
    cd01890
    Location:100 → 277
    LepA; LepA also known as Elongation Factor 4 (EF4)
    PRK05433
    Location:94 → 695
    PRK05433; GTP-binding protein LepA; Provisional
    cd03709
    Location:502 → 581
    lepA_C; lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits ...
    pfam06421
    Location:589 → 695
    LepA_C; GTP-binding protein LepA C-terminus
    cd03699
    Location:285 → 370
    EF4_II; Domain II of Elongation Factor 4 (EF4)
    cd16260
    Location:386 → 461
    EF4_III; Domain III of Elongation Factor 4 (EF4)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86P01 Q86P01
Q9VRH6.2 Q9VRH6

Gene LinkOut

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