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RYBP Ring and YY1 Binding Protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37601, updated on 2-Nov-2024

Summary

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Official Symbol
RYBPprovided by FlyBase
Official Full Name
Ring and YY1 Binding Proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0034763
Locus tag
Dmel_CG12190
See related
AllianceGenome:FB:FBgn0034763
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12190; Dmel\CG12190; drybp; dRYBP; rybp; Rybp
Summary
Enables DNA binding activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of apoptotic process; and negative regulation of immune response. Located in nuclear body. Is expressed in several structures, including adult fat body; larval imaginal tissue; and oocyte. Orthologous to several human genes including YAF2 (YY1 associated factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See RYBP in Genome Data Viewer
Location:
58F7-58F7; 2-100 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22670587..22673212)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18558092..18560717)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45269 Neighboring gene long non-coding RNA:CR42868 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44761 Neighboring gene Partner of paired Neighboring gene long non-coding RNA:CR44762

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. YY1 DNA binding and interaction with YAF2 is essential for Polycomb recruitment. Basu A, et al. Nucleic Acids Res, 2014 Feb. PMID 24285299, Free PMC Article
  2. A novel dRYBP-SCF complex functions to inhibit apoptosis in Drosophila. Fereres S, et al. Apoptosis, 2013 Dec. PMID 23979704
  3. The Drosophila RYBP gene functions as a Polycomb-dependent transcriptional repressor. Bejarano F, et al. Mech Dev, 2005 Oct. PMID 16125914
  4. PcG recruitment by the YY1 REPO domain can be mediated by Yaf2. Wilkinson F, et al. J Cell Biochem, 2010 Feb 15. PMID 19960508, Free PMC Article
  5. Drosophila SCE/dRING E3-ligase inhibits apoptosis in a Dp53 dependent manner. Simoes da Silva CJ, et al. Dev Biol, 2017 Sep 1. PMID 28712876

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data how that dRYBP protein is itself ubiquitylated and binds ubiquitylated proteins.
    Title: dRYBP counteracts chromatin-dependent activation and repression of transcription.
  2. dRYBP-SCF complex inhibit apoptosis in Drosophila.
    Title: A novel dRYBP-SCF complex functions to inhibit apoptosis in Drosophila.
  3. RYBP-induced apoptosis is inhibited by high levels of either p35 or Drosophila Inhibitor of Apoptosis Protein 1, and requires the function of the pro-apoptotic REAPER protein.
    Title: High levels of dRYBP induce apoptosis in Drosophila imaginal cells through the activation of reaper and the requirement of trithorax, dredd and dFADD.
  4. These results indicate that the dRYBP gene functions in the control of cell identity together with the Sex comb extra gene/trithorax gene proteins.
    Title: Functional characterization of the dRYBP gene in Drosophila.
  5. The Ring and YY1 Binding Protein (RYBP) is able to interact with Polycomb group proteins to repress transcription.
    Title: The Drosophila RYBP gene functions as a Polycomb-dependent transcriptional repressor.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in programmed cell death involved in cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nuclear body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ring and YY1 binding protein
Names
CG12190-PA
CG12190-PB
RYBP-PA
RYBP-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    22670587..22673212
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299813.1 → NP_001286742.1  ring and YY1 binding protein, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286742.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T097, Q9W215
    Conserved Domains (2) summary
    sd00030
    Location:23 → 42
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:20 → 43
    zf-RanBP; Zn-finger in Ran binding protein and others

  2. NM_137861.3 → NP_611705.1  ring and YY1 binding protein, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611705.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T097, Q9W215
    Related
    FBpp0071779
    Conserved Domains (2) summary
    sd00030
    Location:23 → 42
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:20 → 43
    zf-RanBP; Zn-finger in Ran binding protein and others
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W215 Q9W215

Gene LinkOut

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